Substance Related Disorders

All Conditions

Behaviors and Mental Disorders

Drug-Related Side Effects and Adverse Reactions

Chemically-Induced Disorders

Quality of Life

Antineoplastic Agents

All Drugs and Chemicals

Oxaliplatin

Capecitabine

Antimetabolites

Randomized group of patients receiving laparoscopic colectomy with conventional perioperative treatment and mFolfox6 chemotherapy.

Randomized group of patients receiving laparoscopic colectomy with Fast Track Multi-Displine（FTMD）treatment and XELOX chemotherapy.

Randomized group of patients receiving open colectomy with conventional perioperative treatment and mFolfox6 chemotherapy.

Randomized group of patients receiving open colectomy with Fast Track Multi-Displine（FTMD） treatment and XELOX chemotherapy.

Laparoscopic surgery for colorectal cancer using STORZ laparoscope

Laparoscopic Surgery for Colorectal Cancer

XELOX Chemotherapy

mFolfox6 chemotherapy

Fast track treatment during perioperation period

Fast Track Perioperative Treatment

Conventional treatment during perioperation period

Conventional Perioperative Treatment

Open surgery for colorectal cancer using conventional methods

Open Surgery for Colorectal Cancer

Ke-Feng Ding, PhD/MD

A new notion"Fast Track Multi-Discipline Treatment" for colorectal cancer is thought with several benefits such as shorter hospitalization stay and less costs. This randomized study aims to compare the differences between conventional and Fast Track Multi-Discipline Treatment for colorectal cancer in hospitalization day, complications, costs and quality of life.

Laparoscopic Surgery, Fast Track Treatment and XELOX Chemotherapy have been introduced in the treatment of colorectal cancer. All of these procedures are contributed to reduce the hospitalization stay. However, the most economical mode for combination of these procedures is still unclear. This is a randomized controlled study, a new notion"Fast Track Multi-Discipline Treatment" is proposed, which is the combination of the Laparoscopic Surgery, Fast track perioperative treatment during perioperative period and XELOX Chemotherapy. The purpose of this study is to compare the Fast Track Multi-Discipline Treatment with the conventional treatment(Open Surgery with conventional treatment during perioperative period and mFolfox6 chemotherapy) for colorectal cancer on several aspects like the average hospitalization day, complications, costs and quality of life.The focus of the study will be to investigate whether the Fast Track Multi-Discipline Treatment reduces hospital stay with similar complications compared with conventional perioperative treatment. Moreover, the trial will clarify whether laparoscopic surgery is essential for Fast Track Multi-Discipline Treatment.

Study Comparing Conventional and Fast Track Multi-Discipline Treatment Interventions for Colorectal Cancer

Randomized Controlled Trial Comparing Conventional and Fast Track Multi-Discipline Treatment Interventions for Colorectal Cancer

The overall hospitalization stay during treatment from the first day in hospital to leave hospital when finish adjuvant chemotherapy or surgery (for patients who don't need chemotherapy).

Surgical complications include injury of ureter, intraoperative transfusion, infection of incision and anastomotic leakage etc.

Chemotherapy related adverse event, according to NCI CTCAE Version 3.0, include nausea, vomit, diarrhea and neutropenia etc.

Quality of life will be measured by EORTC QLQ-C30 and QLQ-CR38 questionaire.

The overall hospitalization costs from the first day in hospital to day that adjuvant chemotherapy finished.

Zhejiang University

Professor of SAHZU

Neoplasms

Digestive System Diseases

Symptoms and General Pathology

Rare Diseases

Stomach Neoplasms

Postoperative Complications

Stomach Cancer

Linear stapler is adopted in esophagojejunostomy.

Circular stapler is adopted in esophagojejunostomy.

Linear stapler is adopted in esophagojejunostomy

Linear stapler

Circular stapler is adopted in esophagojejunostomy

Circular stapler

Yunhong Tian, Doctor

With the development of stapler devices, various methods of esophagojejunostomy after laparoscopic total gastrectomy were evoluated. Which stapler is more advantageous has not been determined. At present, the most commonly used is linear stapler or Circular stapler in esophagojejunostomy. However, there is still a lack of reliable evidence for the selection of the two staplers. The purpose of this study is to explore the advantages of linear staper versus circular stapler in esophagojejunostomy for patients with gastric cancer who underwent total gastrectomy.

With the development of stapler devices, various methods of esophagojejunostomy after laparoscopic total gastrectomy were evoluated. Which stapler is more advantageous has not been determined. At present, the most commonly used is linear stapler or Circular stapler in esophagojejunostomy. However, there is still a lack of reliable evidence for the selection of the two staplers. The purpose of this study is to explore the advantages of linear staper versus circular stapler in esophagojejunostomy for patients with Siewert classification type II and III gastric cancer who underwent total gastrectomy.

Linear Stapler Versus Circular Stapler in Esophagojejunostomy

Linear Stapler Versus Circular Stapler in Esophagojejunostomy for Patients With Gastric Cancer Underwent Laparoscopic Total Gastrectomy

All surgical complication after laparoscopic total gastrectomy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Study Comparing Conventional and Fast Track Multi-Discipline Treatment Interventions for Colorectal Cancer	NCT01080547	Length of Stay Complications Adverse Drug Ev... Quality of Life Hospital Costs	Laparoscopic Su... XELOX Chemother... mFolfox6 chemot... Fast Track Peri... Conventional Pe... Open Surgery fo...	18 Years -	Zhejiang University
Linear Stapler Versus Circular Stapler in Esophagojejunostomy	NCT05360069	Postoperative C... Operative Time Hospital Costs	Linear stapler Circular staple...	18 Years - 90 Years	Nanchong Central Hospital

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