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Pharyngeal Diseases

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Otorhinolaryngologic Diseases

Hélène PÉRÉ, PhD

The aim of this study is to identify HPV molecular signature in head and neck cancer to establish a new classification for positive human papillomavirus oropharyngeal tumor

OROPAP is a monocentric exploratory study with retrospective inclusion of patients.

The retrospective study focus on patients who have had surgery for HPV-positive oropharyngeal tumors whose survival is at least 2 year.

Frozen and or FFPE biopsies of these tumors and frozen blood samples are available via the HEGP biological resources platform.

The HPV molecular signatures will be identified by the capture-HPV technique.

For each patient, clinical-anatomo-pathological data such as tumor size, tumor stage, presence or absence of metastasis, histological stage, different treatment lines and 2-years survival data will be collected through the use of data warehouse available on the HEGP.

Frozen and/or FFPE biopsies of HPV-positive oropharyngeal tumors and frozen blood sample

Molecular Signatures of HPV+ ORL Cancers (OROPAP)

Identification of Specific Molecular Signatures by Capture-HPV and Next-generation Sequencing in HPV-induced Oropharyngeal Cancers

Individual participant data that underlie results in publication could be shared. Individual participant data detailed in meta analysis protocol could be shared

Establish a new classification based on HPV molecular signature for positive human papillomavirus oropharyngeal tumor

Find in the peripheral blood of patients, the presence of circulating tumoral HPV DNA (ctDNA) by droplet based digital PCR and when it is possible compare chromosomal insertion patterns of HPV ct DNA as those found in tumors

Look for an association between the presence of specific HPV molecular signatures and clinical-anatomo-pathological data.

Look for an association between the presence of these molecular signatures and the survival of patients.

Measure the viral load of HPV in the tumor.

Identify disrupted metabolic pathways in tumor cells.

Analyze of complete viral genomes and identify potential variants through sequencing data analysis

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Molecular Signatures of HPV+ ORL Cancers (OROPAP)	NCT04189003	Oropharyngeal C... Human Papilloma...		18 Years -	Assistance Publique - Hôpitaux de Paris
Molecular Signatures of HPV+ ORL Cancers (OROPAP)	NCT04189003	Oropharyngeal C... Human Papilloma...		18 Years -	Assistance Publique - Hôpitaux de Paris

Spots Global Cancer Trial Database for hpv+ tumor

Every month we try and update this database with for hpv+ tumor cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for hpv+ tumor

Every month we try and update this database with for hpv+ tumor cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for hpv+ tumor cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.