Spots Global Cancer Trial Database for Molecular Signatures of HPV+ ORL Cancers (OROPAP)

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Trial Identification

Brief Title: Molecular Signatures of HPV+ ORL Cancers (OROPAP)

Official Title: Identification of Specific Molecular Signatures by Capture-HPV and Next-generation Sequencing in HPV-induced Oropharyngeal Cancers

Study ID: NCT04189003

Conditions

Oropharyngeal Cancer

Human Papillomavirus-Related Carcinoma

Interventions

Study Description

Brief Summary: The aim of this study is to identify HPV molecular signature in head and neck cancer to establish a new classification for positive human papillomavirus oropharyngeal tumor

Detailed Description: OROPAP is a monocentric exploratory study with retrospective inclusion of patients. The retrospective study focus on patients who have had surgery for HPV-positive oropharyngeal tumors whose survival is at least 2 year. Frozen and or FFPE biopsies of these tumors and frozen blood samples are available via the HEGP biological resources platform. The HPV molecular signatures will be identified by the capture-HPV technique. For each patient, clinical-anatomo-pathological data such as tumor size, tumor stage, presence or absence of metastasis, histological stage, different treatment lines and 2-years survival data will be collected through the use of data warehouse available on the HEGP.