Symptoms and General Pathology

All Conditions

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Rare Diseases

Recurrence

Carcinoma

Small Cell Lung Carcinoma

Lung Neoplasms

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Small Cell Lung Cancer

Antineoplastic Agents

All Drugs and Chemicals

Temozolomide

Antineoplastic Agents, Alkylating

Alkylating Agents

Escalating doses of HTMC0435 and Temozolomide

Recommended phase 2 dose (RP2D) of HTMC0435 and Temozolomide

HTMC0435

Jun Li

Yun Fan, MD

The Phase 1b part of this clinical trial is to investigate the safety and pharmacokinetic (PK) characteristics of HTMC0435 tablets combined with temozolomide in patients with various advanced solid tumors (recurrent small cell lung cancer is preferred). The Phase 2 part of the study is a multi-center, open-label, single-arm trial to investigate the preliminary efficacy of HTMC0435 and temozolomide in patients with recurrent small cell lung cancer (SCLC) at the recommended phase 2 dose.

HTMC0435 and Temozolomide in Treating Patients With Small Cell Lung Cancer

A Phase 1b/2, Dose-finding and Expansion Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HTMC0435 With Temozolomide in Patients With Small Cell Lung Cancer

Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
HTMC0435 and Temozolomide in Treating Patients With Small Cell Lung Cancer	NCT05728619	Recurrent Exten...	HTMC0435 Temozolomide	18 Years - 75 Years	Shanghai Huilun Pharmaceutical Co., Ltd.
HTMC0435 and Temozolomide in Treating Patients With Small Cell Lung Cancer	NCT05728619	Recurrent Exten...	HTMC0435 Temozolomide	18 Years - 75 Years	Shanghai Huilun Pharmaceutical Co., Ltd.

Spots Global Cancer Trial Database for htmc0435

Every month we try and update this database with for htmc0435 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for htmc0435

Every month we try and update this database with for htmc0435 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for htmc0435 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.