Diseases and Abnormalities at or Before Birth

All Conditions

Nervous System Diseases

Heart and Blood Diseases

Neoplasms

Rare Diseases

Congenital Abnormalities

Intracranial Arteriovenous Malformations

Arteriovenous Malformations

Hemangioma

Vascular Malformations

Cardiovascular Abnormalities

Vascular Diseases

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Cerebrovascular Disorders

Brain Diseases

Central Nervous System Diseases

Central Nervous System Vascular Malformations

Nervous System Malformations

Intracranial Arterial Diseases

Intracranial Arteriovenous Malformation

Unsimultaneous endovascular interventional embolisation/radiotherapy followed by microsurgical resection, as traditional clinical routines.

A one-stage hybrid operation combining endovascular intervention and microsurgical techniques will be conducted simultaneously

A one-stage cooperation of existing endovascular interventional techniques and microsurgical techniques, including microsurgical resection, endovascular embolization, balloon occlusion.

hybrid operating techniques

To evaluate the clinical benefits and risks of hybrid operating techniques in management of cerebral arteriovenous malformations.

Purpose: Have an evaluation of clinical benefits and risks of hybrid operating techniques in management of cerebral arteriovenous malformations(AVMs). Meanwhile, as a new cooperative interventional modality, optimized workflows, technical key knots and operation routines will be explored in the study.

Objects: Patients with cerebral arteriovenous malformations, coincident with inclusion and exclusion criterion and admitted in participating organizations.

Methods: Patients will be distributed into 2 groups, including traditional therapy group(control group) and hybrid operating group(trial group), and conduct with traditional neurosurgical management or one-stage hybrid operating management correspondingly. Residual rate of AVM is considered to be the primary observing indicator, and morbidity rate of post-operative complications, post-operative mortality rate, and morbidity rate of neural functional deterioration are secondary indicators.The information of operations will be recorded in detail as evidence of optimization of workflow and technical key knots.

Traditional therapy group：traditional management of AVMs, such as unsimultaneous endovascular interventional embolisation, radiotherapy followed by microsurgical resection, will be conducted to patients involved in this group.

Hybrid operation group: A one-stage hybrid operation combining endovascular intervention and microsurgical techniques will be conducted simultaneously to patients in this group.

Surgical Management of Cerebral Arteriovenous Malformations Within Hybrid Operation Room

The instant post-operative residual rate of AVMs

3 months' residual rate after AVM operation

6 months' residual rate after AVM operation

1 year's residual rate after AVM operation

Include intracranial hemorrhage or infarction, infection of central neural system, infection of respiratory system, cranial nerve deficits, and other symptomatic complications

The score of modified Rankin Scale increases ≥2

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Surgical Management of Cerebral Arteriovenous Malformations Within Hybrid Operation Room	NCT03209804	Intracranial Ar...	hybrid operatin...	18 Years - 70 Years	Ministry of Science and Technology of the People´s Republic of China
Surgical Management of Cerebral Arteriovenous Malformations Within Hybrid Operation Room	NCT03209804	Intracranial Ar...	hybrid operatin...	18 Years - 70 Years	Ministry of Science and Technology of the People´s Republic of China
Surgical Management of Cerebral Arteriovenous Malformations Within Hybrid Operation Room	NCT03209804	Intracranial Ar...	hybrid operatin...	18 Years - 70 Years	Ministry of Science and Technology of the People´s Republic of China

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