Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

conventional I:E ratio group, inspiratory time : expiratory time = 1:1

conventional I:E ratio of 1:2 is applied. Ventilator : Datex-Ohmeda Aestiva/5 ® model

Conventional I:E ratio

I:E ratio of 1:1 is applied Ventilator : Datex-Ohmeda Aestiva/5 ® model

I:E = 1:1 ratio

Sangmin M. Lee, MD, PhD

Won Ho Kim, MD

Pulmonary gas exchange disturbance is a common anesthetic problem during one-lung ventilation (OLV) for thoracic surgery. The inverse-ratio ventilation (IRV), which prolongs the inspiratory time greater than expiratory time, can be applied for adult respiratory distress syndrome. The effect of IRV is to improve gas-exchange status by increasing mean airway pressure and alveolar recruitment. We tried to evaluate the effect of IRV during OLV with lung protective strategy.

Pulmonary gas exchange disturbance is a common anesthetic problem during one-lung ventilation (OLV) for thoracic surgery. Continuous positive airway pressure or positive end-expiratory pressure are usually applied to improve this disorder including hypoxia, but these methods are not enough. The inverse-ratio ventilation (IRV), which prolongs the inspiratory time greater than expiratory time, can be applied for adult respiratory distress syndrome. The effect of IRV is to improve gas-exchange status by increasing mean airway pressure and alveolar recruitment. The application of IRV during OLV has not been performed to our knowledge, and there is a possibility of IRV to improve oxygenation during OLV. There is a possibility of increase of auto-PEEP, or air trapping in subjects with chronic obstructive pulmonary disease, but this kind of auto-PEEP can be overcome by external PEEP. Therefore, we tried to evaluate the effect of IRV during OLV with lung protective strategy.

The Effect of Different I:E Ratio on Gas Exchange of Patients Undergoing One-lung Ventilation for Lung Surgery

systolic/ diastolic blood pressure, heart rate, mean blood pressure

physiologic dead space / tidal volume (VD/VT)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effect of Different I:E Ratio on Gas Exchange of Patients Undergoing One-lung Ventilation for Lung Surgery	NCT01540201	Lung Cancer One Lung Ventil... Gas Exchange Inverse-ratio V...	Conventional I:... I:E = 1:1 ratio	20 Years - 70 Years	Samsung Medical Center
The Effect of Different I:E Ratio on Gas Exchange of Patients Undergoing One-lung Ventilation for Lung Surgery	NCT01540201	Lung Cancer One Lung Ventil... Gas Exchange Inverse-ratio V...	Conventional I:... I:E = 1:1 ratio	20 Years - 70 Years	Samsung Medical Center
The Effect of Different I:E Ratio on Gas Exchange of Patients Undergoing One-lung Ventilation for Lung Surgery	NCT01540201	Lung Cancer One Lung Ventil... Gas Exchange Inverse-ratio V...	Conventional I:... I:E = 1:1 ratio	20 Years - 70 Years	Samsung Medical Center

Spots Global Cancer Trial Database for i:e = 1:1 ratio