Neoplasms

All Conditions

Musculoskeletal Diseases

Rare Diseases

Sarcoma

Bone Neoplasms

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Soft Tissue Sarcoma

Patients with suspected or confirmed bone or soft tissue tumors undergoing biopsy or surgery

Identification and characterization of molecular markers in musculoskeletal tumors

The aim of the study is to improve the understanding of molecular mechanisms in the development and progression of musculoskeletal tumors. These tumors do have in general unfavorable prognosis and conventional treatments (e.g. surgery, radiotherapy or chemotherapy) could not enhance the prognosis of these patients during the last ten to fifteen years. Therefore the investigators chose a new way, as they try to identify markers on a genetic level, who ideally act as a basis to develop new treatment options.

To definitely asses such molecular markers in musculoskeletal tumors they have to be identified in human patient samples with corresponding tumors, before molecular markers can be validated in animal models. Just because these soft tissue and bone tumors are rare (compared to breast and lung carcinomas), it is of great importance that samples from all patients treated at Balgrist University Hospital are collected systematically und stored correspondingly. Only like this valid statements can be done. Therefore the investigators intent to collect tissue and blood samples from all patients who agree in participating in the study. The samples will be taken during routine biopsies and operations. To compare tumor tissue and healthy tissue it is also planed to take samples from tumor free patients who undergo a knee replacement surgery. The investigators would store the surgical waste and involve these samples in the analyzes.

Clinical data regarding diagnosis and examination findings, as well as tissue from biopsies and surgeries will be collected prospectively. The tissue will be frozen in liquid nitrogen according to standard procedures and stored until the molecular analyzes at the Laboratory of Orthopedic Research at Balgrist University Hospital. The processing involves expression analyzes such as polymerase chain reaction, Western Blot, micro arrays, immunohistochemistry and tissue array. The DNA from the taken blood samples shall be compared with the DNA found in the tumor.

blood serum blood plasma tumor tissue tumor free tissue

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Identification and Characterization of Molecular Markers in Musculoskeletal Tumors	NCT02199938	Soft Tissue and... Sarcoma Sarcoma of Bone Soft Tissue Sar...	Identification ...	-	Balgrist University Hospital
Identification and Characterization of Molecular Markers in Musculoskeletal Tumors	NCT02199938	Soft Tissue and... Sarcoma Sarcoma of Bone Soft Tissue Sar...	Identification ...	-	Balgrist University Hospital
Identification and Characterization of Molecular Markers in Musculoskeletal Tumors	NCT02199938	Soft Tissue and... Sarcoma Sarcoma of Bone Soft Tissue Sar...	Identification ...	-	Balgrist University Hospital

Spots Global Cancer Trial Database for identification and characterization of molecular markers in musculoskeletal tumors