The dielectric properties of the tissues were measured using the open-ended coaxial line method. The measurement system consisted of a network analyzer (Model 4395A, Agilent Corp., Santa Clara, CA) associated with an S-parameter test set (Model 87511A, Agilent Corp., Santa Clara, CA). A semi-rigid coaxial line with a diameter of 3.58 mm was connected to the network analyzer system by using a Bayonet Neill-Concelman connector. The other tip of the coaxial line (probe) was placed on the flat bare surface of the tissue.

network analyzer

Sherman X Xin, professor

Yu Yanhong, Professor

Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. However the EP information mainly based on ex vivo measurement of cancer tissues, and few data in vivo were published. The purpose of this study is to in vivo measure the electrical properties of the malignant tissues.

The measurements were safety guaranteed and were conducted during the cancer surgeries. Before the tissue was excised from the patient,the pathologist assisted the operator (already at the operating room) responsible for the measurement.The measurement of malignant and corresponding normal tissues were both performed. The tissues for dielectric properties measurement were classified as normal or malignant by the pathologist based on his own expertise and decision criteria (visual inspection, anatomy) and the per-operative histological examination. The measurements were directly performed on the tissue before excision.The sites of the measured malignant tissues were marked,doubletracked according to the pathological report to make sure the marked sites are malignant. The patient age and tissue temperature at the time of measurement were recorded.

Measuring the Electrical Properties of Malignant Tissues In Vivo

Measuring the Electrical Properties of the Malignant Tissues During Cancer Surgeries

Zhujiang Hospital

Nanfang Hospital, Southern Medical University

Southern Medical University, China

Professor

Low intensity amplitude-modulated RF EMFs

Low intensity amplitude-modulated radiofrequency electromagnetic fields,the carrier frequency is 27.12MHz with a power of about 100mW

Xin Sherman Xuegang, professor

Cai Linbo, master

Zhu Xiaoxia, PhD

Liu Xiantang, bachelor

Studies have shown that tumor specific amplitude-modulated frequencies of radiofrequency electromagnetic fields that is associated with biofeedback upon exposure to in cancer patients. However, such discovery in other cancer patients are rare. And whether tumor specific frequencies can be found in Asian cancer patients remains unclear. The purpose of this study is to detect the tumor specific frequencies of Asian cancer patients in vivo.

The measurements were safety guaranteed and were conducted in hospital. Before detecting, the patient will be already diagnosed with cancer. The doctor and the operator are responsible for the detecting. When cancer patients are exposure to the RF electromagnetic fields, the radial pulse amplitude, blood pressure, skin electrical resistance and breath will be monitored. Biofeedback parameters will be recorded at different modulation frequencies and analyzed in order to find the variation and tumor specific frequencies.

Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients

Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients In Vivo

Guangdong 999 Brain Hospital

The 157th Hospital of PLA,China

Neoplasms

Digestive System Diseases

All Conditions

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Rectal Diseases

Confocal laser endomicroscopy optical biopsy will be performed in surgery for patients assigned to this group

Intra-operative frozen section will be performed for patients assigned to this group

In the pCLE group, after intravenous injection of fluorescein, the optical biopsy will be performed, using a confocal miniprobe, to exam the rectal mucosa when the rectum transection is ready. The raters will analyse the CLE images to determine whether the distal margin is positive. In the IFS group, intra-operative frozen section will be performed at the site of distal margin after the rectum transection.

Probe-based confocal laser endomicroscopy optical biopsy

Intra-operative frozen section

Jun Yan, M.D., Ph.D

This is a multi-center prospective randomized controlled study. In this study, the investigators will use confocal laser endomicroscopy to make real-time in vivo optical biopsy of distal margin in rectal cancer surgery and help surgeons to make surgical decision.The investigators also assess the accuracy of CLE optical biopsy, compared with intra-operative frozen section.

In low rectal cancer surgery, how to select the precise dissection plane and optimal surgical procedure is an important challenge for surgeons. In current clinic, surgeons select dissection plane by a comprehensive judgment of pre-operative pelvis MRI, colonoscopy and digital rectal examination, then through submitting the "doughnut" after cutting and anastomosis to intra-operative frozen section (IFS) to definite whether there is residual tumor in distal margin (DM). However, IFS can only make diagnosis using the tissue specimen in vitro and time-consuming. Once the IFS confirm positive margin, it always means anal resection should be implemented to ensure radical treatment. Therefore, if there is a real-time in situ examination method to evaluate DM in vivo, it will bring great benefits to both surgeons and patients.

Confocal laser endomicroscopy (CLE) had been widely used in medical field to diagnose colorectal disease, but it is seldom applied in surgical filed especially in rectal cancer to make optical biopsy and help surgical decision-making. Therefore, the investigators hypothesize that CLE can real-time in situ evaluate DM during surgery in rectal cancer and its accuracy is non-inferior to intra-operative frozen section.

In this study, the investigators will randomly assign patients to the experimental group (CLE optical biopsy) and control group (IFS). Using H-E staining pathological diagnosis as golden standard, the accuracy, sensitivity and specificity of both CLE optical biopsy and IFS will be evaluated and compared. And the investigators will also evaluate patients' postoperative urinary function, defection function and quality of life through a year follow-up.

Optical Biopsy for Distal Margin in Low Rectal Cancer

A Multicenter Randomized Study of Real-time In-vivo Confocal Laser Endomicroscopy Optical Biopsy for Distal Margin in Low Rectal Cancer Compared to Intraoperative Frozen Section

Accuracy of confocal laser endomicroscopy optical biopsy of distal margin is determined by the pathology result.

Sensitivity and specificity of confocal laser endomicroscopy optical biopsy of distal margin are determined by the pathology result.

Defecation and sphincter function will be combined to report Wexner score.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Measuring the Electrical Properties of Malignant Tissues In Vivo	NCT02747225	Neoplasms	network analyze...	-	Southern Medical University, China
Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients	NCT03037840	Neoplasms	Low intensity a...	-	Southern Medical University, China
Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients	NCT03037840	Neoplasms	Low intensity a...	-	Southern Medical University, China
Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients	NCT03037840	Neoplasms	Low intensity a...	-	Southern Medical University, China
Optical Biopsy for Distal Margin in Low Rectal Cancer	NCT04016948	Rectal Cancer	Probe-based con... Intra-operative...	18 Years - 70 Years	Nanfang Hospital, Southern Medical University

Spots Global Cancer Trial Database for in vivo

Every month we try and update this database with for in vivo cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for in vivo

Every month we try and update this database with for in vivo cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for in vivo cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.