Spots Global Cancer Trial Database for rectal cancer

Every month we try and update this database with for rectal cancer cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Stoma Discharge Reinfusion After Sphincter Preservation for Middle and Low Rectal Cancer	NCT05461248	Rectal Cancer	stoma drainage ... Standard of Car...	18 Years - 75 Years	The First Hospital of Jilin University
IMRT Versus 3DCRT for Locally Advanced Rectal Cancer, Prospective Phase II Study.	NCT06160570	Rectal Cancer Radiotherapy Toxicity Due to...	Intensive Modul... 3-Dimension Con...	18 Years -	Rabin Medical Center
Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab to Assess Safety and Immune Activation in Patients With Locally Advanced Primary and Recurrent Oncogenic RAS Exon 2 Mutant Colorectal Cancer	NCT02933944	Rectal Cancer	TG02-treatment Pembrolizumab	18 Years -	Targovax ASA
Anastomotic Leakage After Anterior Resection of Rectal Cancer	NCT03281070	Rectal Cancer		-	Beijing Friendship Hospital
ELRR by TEM Versus Laparoscopic TME in iT2N0M0 SMALL LOW RECTAL CANCER	NCT01609504	Rectal Cancer	ELRR BY TEM LTME	-	University of Roma La Sapienza
Ketogenic Diet Compliance in Patients Affected by Locally Advanced Rectal Cancer Patients Who Undergo to Radiotherapy	NCT05938322	Rectal Cancer	Ketogenic Diet Standard Diet	18 Years - 75 Years	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Induction Chemotherapy for Locally Advanced Rectal Cancer	NCT04838496	Rectal Cancer	FOLFOXIRI Proto...	18 Years -	Catharina Ziekenhuis Eindhoven
Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer	NCT02353858	Rectal Cancer Locally Advance... Hyperthermia Hyperthermic Ra... Hyperthermic Ch... Deep Regional H...	Deep regional h... Radiotherapy Chemotherapy (5...	18 Years - 80 Years	University Hospital Tuebingen
Comparing Preoperative Short-course Radiotherapy With or Without Local Boost for Rectal Cancer	NCT02498353	Rectal Cancer	preoperative sh... preoperative sh... TME surgery	18 Years - 70 Years	Zhongnan Hospital
IPC Status as a Surgical Quality Marker in Rectal Cancer Surgery	NCT02081547	Rectal Cancer		18 Years -	Uppsala University
The Role of Transanal Tube Drainage as A Mean of Prevention of Anastomotic Leakage Anastomotic Leakage	NCT03325361	Rectal Cancer Rectal Neoplasm... Anastomotic Lea...	Tube drain inse...	-	University of Rome Tor Vergata
Multicenter, Prospective, RCT：Investigation of Combined Modality Therapy for Locally Advanced Mid/Low Rectal Cancer.	NCT03042000	Rectal Cancer, ... Neoadjuvant Che...	non-NCRT NCRT capecitabine wi... capecitabine TEM radical resecti...	18 Years - 75 Years	Peking Union Medical College Hospital
Comparison of Robotic Versus Laparoscopic Surgery for Visceral Obesity in Mid-Low Rectal Cancer: A Propensity-Matched Analysis	NCT06397053	Visceral Obesit... Rectal Cancer Robotic Surgery	robotic surgery	18 Years - 90 Years	Northern Jiangsu People's Hospital
Promoting Physical Activity After Colorectal Cancer	NCT00230646	Colon Cancer Rectal Cancer	Exercise counse...	18 Years -	The Miriam Hospital
Survivor Choices for Eating and Drinking - Colorectal Cancer	NCT02965521	Colon Cancer Rectal Cancer ColoRectal Canc...	Website and tex...	18 Years -	University of California, San Francisco
Trial Comparing Loop Ileostomy Versus Loop Transverse Colostomy	NCT05745909	Rectal Neoplasm... Ostomy Neoplasms	Laparoscopic or... Laparoscopic or...	18 Years - 79 Years	Republican Clinical Oncological Dispensary, Ministry of Health of the Republic of Bashkortostan
Assessment of Clinically Related Outcomes and Biomarker Analysis for Translational Integration in Colorectal Cancer	NCT01762813	Colorectal Canc...	open and laparo...	18 Years -	Helse Stavanger HF
Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type, PIK3CA-Mutated, Colorectal Cancer	NCT01186705	Colon Cancer Rectal Cancer	MK-2206	18 Years -	Memorial Sloan Kettering Cancer Center
Safety Study of 90Y-hMN14 to Treat Colorectal Cancer	NCT00040599	Colorectal Canc... Colon Cancer Rectal Cancer Colorectal Neop... Colorectal Carc... Colorectal Tumo...	hMN14 (labetuzu...	18 Years -	Gilead Sciences
Total Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE)	NCT05646511	Locally Advance...	SCRT CAPOX CAPOXIRI	18 Years -	National Cancer Center Hospital East
Preoperative Chemoradiotherapy Utilizing Intensity Modulated Radiation Therapy in Combination With Bevacizumab-FOLFOX	NCT01395667	Rectal Cancer	CCRT	20 Years - 70 Years	National Taiwan University Hospital
Total Neoadjuvant Therapy With Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Ultra Low Rectal Adenocarcinoma	NCT05858567	Rectal Cancer	Envafolimab	18 Years -	Sir Run Run Shaw Hospital
Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer	NCT00903396	Anal Cancer Carcinoma of th... Colorectal Canc... Extrahepatic Bi... Gallbladder Can... Gastric Cancer Gastrointestina... Liver Cancer Nausea and Vomi... Pancreatic Canc... Primary Periton... Small Intestine...	palonosetron hy... placebo	18 Years -	Alliance for Clinical Trials in Oncology
The Role of TextRAd on Detection of Liver Metastasis in Rectal Cancer	NCT05398822	Rectal Cancer	MRI	-	East Suffolk and North Essex NHS Foundation Trust
Action of Synbiotics on Irradiated GI Mucosa in Rectal Cancer Treatment	NCT03420443	Rectal Cancer	Oat bran Oat bran and bl... No oral supplem...	18 Years - 80 Years	Region Skane
Comparison of Short-term Efficacy and Long-term Prognosis for Reduction Surgery and Radical Resection in Almost-cCR Rectal Cancer Patients	NCT03431428	Almost-cCR Surgery Rectal Cancer	transanal surge... Miles surgery Preoperative ch...	18 Years - 75 Years	Liaoning Tumor Hospital & Institute
Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen	NCT04340401	Rectal Cancer	SHR-1210 Oxaliplatin Capecitabine Intensity modul... Total mesorecta...	18 Years - 70 Years	Peking University Cancer Hospital & Institute
One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy	NCT00358397	Tumors	Clostridium nov...	18 Years -	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer	NCT05939661	Rectal Cancer	Radiation Chemotherapy Surgery	18 Years -	Osaka University
Induction Therapy With Panitumumab + mFOLFOX-6 in Rectal Cancer and Quadruple Wild-type Mutation Before Surgery	NCT03000374	Rectal Cancer	Panitumumab 5Fluorouracil Oxaliplatin Leucovorin	18 Years - 74 Years	Grupo Espanol Multidisciplinario del Cancer Digestivo
Complete Pathologic Response Rectal Cancers	NCT03351959	Rectal Cancer	neo-adjuvant tr...	18 Years -	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Local Excision for Organ Preservation in Early REctal Cancer With No Adjuvant Treatment	NCT05927584	Rectal Cancer Rectum Neoplasm	Transanal local...	18 Years -	Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Impact of Bladder Depletion on Mesorectal Movements During Radiotherapy in Rectal Cancer	NCT04323722	Rectal Cancer	Empty Bladder p...	18 Years -	Institut Cancerologie de l'Ouest
Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi)	NCT06229041	Rectal Cancer	Camrelizumab ＋I...	18 Years - 75 Years	Peking University Cancer Hospital & Institute
MRI Guided SIB Radiotherapy in Neoadjuvant Therapy for Advanced Rectal Cancer	NCT06246344	Rectal Cancer	MRI Guided Simu...	18 Years - 75 Years	Shandong Cancer Hospital and Institute
Evaluation of Protein in the Urine in Patients Receiving Bevacizumab	NCT00849394	Colon Cancer Rectal Cancer		18 Years -	North Texas Veterans Healthcare System
SHOrt Course Radiation and TASOX (TAS102 Plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer	NCT04417699	Rectal Cancer	TAS 102 Oxaliplatin	18 Years -	Providence Health & Services
Rectal Preserving Treatment for Early Rectal Cancer. A Multi-centred Randomised Trial of Radical Surgery Versus Adjuvant Chemoradiotherapy After Local Excision for Early Rectal Cancers	NCT02371304	Rectal Cancer	Adjuvant chemor... Additional TME ... capecitabine	18 Years -	Amsterdam UMC, location VUmc
Organ Preservation in Elderly Patients With Rectal Cancer	NCT01863862	Rectal Cancer	Radiochemothera...	70 Years -	Maria Sklodowska-Curie National Research Institute of Oncology
Pelvic Drain After Rectal Resection for Mid-low Rectal Cancer	NCT04573621	Rectal Cancer	Pelvic drain No pelvic drain...	18 Years -	Hospital Universitari Vall d'Hebron Research Institute
Evaluate Efficacy, Morbidity and Functional Outcome of Endoscopic TranAnal Proctectomy vs Standard Transabdominal Laparoscopic Proctectomy for Rectal Cancer	NCT02584985	Rectal Cancer	ETAP Standard Transa...	18 Years -	Institut Paoli-Calmettes
Carnoy's Solution Versus Formalin in Rectal and Gastric Cancer Specimens Following: a Randomized Trial	NCT02629315	Rectal Cancer Gastric Adenoca...	Carnoy's soluti... 10% neutral buf...	18 Years - 80 Years	Instituto do Cancer do Estado de São Paulo
Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed	NCT00002527	Colorectal Canc...	aspirin placebo	30 Years - 74 Years	Alliance for Clinical Trials in Oncology
A Randomized Controlled Trial of the Safety and Efficacy of Robotic Telesurgery Versus Laparoscopic Surgery	NCT06369597	Liver Cancer Renal Cancer Rectal Cancer	Robotic telesur... Laparoscopic su...	18 Years - 75 Years	Sun Yat-sen University
Radiomics in Rectal Cancer	NCT05331040	Rectal Cancer	MRI	18 Years -	NHS Grampian
Simple Transanal Local Excision，Transanal Local Excision Following Radiotherapy Versus Total Mesorectum Excision for the Treatment of the Ultra-low T2N0M0 Rectal Cancer	NCT04098471	Rectal Cancer	transanal local...	18 Years - 80 Years	The First Affiliated Hospital with Nanjing Medical University
The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)	NCT06222255	Low Anterior Re... Rectal Cancer Insomnia Sleep Disorder	Transanal Irrig...	19 Years - 80 Years	Seoul National University Hospital
Patient Reported Outcomes Following Cancer of the Rectum	NCT04936581	Sphincter Ani I... Rectal Cancer	Open Total Meso... Laparoscopic To... Robotic Total M... Transanal Total...	18 Years - 100 Years	University Hospital Gregorio Marañón
Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients	NCT03921684	Rectal Cancer	Capecitabine Radiation thera... mFOLFOX6 Nivolumab	18 Years -	Rabin Medical Center
Perineal Flap Reconstruction Following Surgery for Advanced Pelvic Malignancy	NCT05074082	Pelvic Cancer Rectal Cancer Flap Disorder Flap Ischemia Flap Necrosis Perioperative C...	Flap reconstruc...	18 Years -	St Vincent's University Hospital, Ireland
Patient Reported Outcomes Following Cancer of the Rectum	NCT04936581	Sphincter Ani I... Rectal Cancer	Open Total Meso... Laparoscopic To... Robotic Total M... Transanal Total...	18 Years - 100 Years	University Hospital Gregorio Marañón
Hartmanns Procedure or Abdominoperineal Excision With Intersphincteric Dissection in Rectal Cancer: a Randomized Study	NCT01995396	Rectal Cancer Sphincter Ani I... Other Diagnoses...	APE with inters... Hartmann´s proc...	18 Years -	Region Västmanland
Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX Chemotherapy for Rectal Cancer	NCT01659424	Rectal Cancer	High Dose Rate ...	18 Years -	Beth Israel Medical Center
Total Neoadjuvant Therapy With Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Ultra Low Rectal Adenocarcinoma	NCT05858567	Rectal Cancer	Envafolimab	18 Years -	Sir Run Run Shaw Hospital
Prevention of Acute Voiding Difficulty After Radical Proctectomy	NCT00606983	Rectal Cancer Urinary Retenti...	Tamsulosin	20 Years - 80 Years	Seoul National University Hospital
Robotic-assisted Versus Conventional Laparoscopic Approach for Rectal Cancer Surgery	NCT03589131	Rectal Cancer	Total Operative... Margin assessme... Conversion rate... Baseline demogr... Preoperative da... Postoperative d...	16 Years - 75 Years	National Cancer Institute, Egypt
Reinforcement of Rectal Anastomosis-RORA	NCT02589483	Rectal Cancer	The rectal anas... Hemopatch	-	Capio Sankt Görans Hospital
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer	NCT03565029	Colo-rectal Can...	XELOX Radiotherapy	18 Years -	Niguarda Hospital
Pathology Assessment of Mesorectal Fascia After TME by Laparoscopic, Open, TransAnal and Robotic Approaches (LOTARTME)	NCT04949672	Rectal Cancer Surgery		-	San Giovanni Addolorata Hospital
Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combination With Chemotherapy With/Without Bevacizumab for Hepatic Metastases From Colorectal Cancer	NCT00200200	Hepatic Metasta... Colon Cancer Rectal Cancer	Bevacizumab HAI... HAI plus system...	19 Years -	Memorial Sloan Kettering Cancer Center
Preoperative Chemoradiation With VMAT-SIB in Rectal Cancer	NCT02745639	Rectal Neoplasm...	VMAT-SIB XELOX	18 Years -	IRCCS Azienda Ospedaliero-Universitaria di Bologna
High Dose Radiotherapy for the Treatment of Rectal Cancer	NCT03541304	Rectal Cancer		18 Years - 80 Years	Sun Yat-sen University
Procedure RACHEL in Complex Treatment of Rectal Cancer	NCT02022553	Rectal Cancer T...	usual rectal ca... RACHEL	18 Years - 75 Years	Voronezh N.N. Burdenko State Medical Academy
Computer Navigation-assisted Surgery for Locally Advanced and Recurrent Rectal Cancer	NCT04512937	Rectal Cancer	Computer-assist...	18 Years -	Oslo University Hospital
Functional Outcomes and Quality of Life in Patients Undergoing Surgery for Rectal Cancer	NCT00579579	Rectal Cancer	Questionaires	18 Years -	Memorial Sloan Kettering Cancer Center
Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer	NCT00068692	Rectal Mucinous... Rectal Signet R... Recurrent Recta... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect... Stage IVA Recta... Stage IVB Recta...	Radiotherapy Fluorouracil Leucovorin Calc... Oxaliplatin Irinotecan	18 Years -	National Cancer Institute (NCI)
FOLFOXIRI With or Without Intensification for Rectal Cancer	NCT03997435	Rectal Cancer	Control arm Experimental ar...	18 Years -	Chinese University of Hong Kong
Patient Activation Intervention in Improving Screening Rates for Colorectal Cancer	NCT01801059	Colon Cancer Rectal Cancer	educational int... educational int... questionnaire a...	50 Years -	Ohio State University Comprehensive Cancer Center
Randomized Controlled Study on Optimize Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer	NCT02031939	Advanced Rectal...	Induction chemo... standard chemor...	18 Years - 75 Years	Sun Yat-sen University
Pilot Study Evaluating the Efficacy of AlloMEM After Loop Ileostomy	NCT01113736	Colon Cancer Rectal Cancer	AlloMEM™	18 Years -	University Hospitals Cleveland Medical Center
A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer	NCT05939661	Rectal Cancer	Radiation Chemotherapy Surgery	18 Years -	Osaka University
PTC Drug Sensitivity Detection to Guide Postoperative Adjuvant of Colorectal Cancer	NCT05978349	Colo-rectal Can...	adjuvant therap...	18 Years - 75 Years	Peking Union Medical College Hospital
Online Adaptive Radiation Therapy for Rectal Cancer	NCT05911789	Rectal Cancer	Online adaptive...	18 Years -	Peking Union Medical College Hospital
A Prospective Feasibility Study for TAMIS	NCT02626728	Rectal Cancer	laparoscopic as...	18 Years - 99 Years	Hvidovre University Hospital
Capecitabine in the Perioperative Treatment of Rectal Cancer	NCT01500993	Rectal Cancer	Capecitabine 5-FU	18 Years -	Universitätsmedizin Mannheim
A Study of Bevacizumab (Avastin) in Participants With Newly Diagnosed Locally Advanced Rectal Cancer	NCT00865189	Rectal Cancer	Bevacizumab Oxaliplatin Folinic Acid 5-fluorouracil Preoperative Ra... Surgery	18 Years - 75 Years	Hoffmann-La Roche
High Dose Vitamin D Study	NCT01150877	Colorectal Canc...	Vitamin D	18 Years -	University of British Columbia
Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma	NCT02935309	Rectal Cancer Rectal Adenocar...	Lenvatinib Capecitabine External Radiat...	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery	NCT02177084	Rectal Cancer Low Anterior Re...	PTNS	18 Years - 80 Years	IRCCS Azienda Ospedaliero-Universitaria di Bologna
Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients	NCT06043999	Chemotherapy Ef... Rectal Cancer	Radical total m... Salavge Adjuvan...	18 Years - 75 Years	Sun Yat-sen University

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

Join others from around the world: