Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Multiple Pulmonary Nodules

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

All Drugs and Chemicals

Autoantibodies

Immunologic Factors

Patients with definite lung cancer diagnosis

Either patients with benign pulmonary nodule, or healthy individuals without pulmonary nodule but with risk factors to develop lung cancer matched to lung cancer group

Level of a set of autoantibodies potentially relative with lung cancer will be tested for each of the participants.

Tumor autoantibody detection

Chunxue Bai, MD

Jian Zhou, MD

Jiayuan Sun, MD

Xiaoju Zhang

Lung cancer is the most common cancer in China from both incidence and mortality rate point of view, with significantly lower 5-year survival rate than average. Early detection is the recognized solution. LDCT is more and more popular accepted as an effective screening methodology but leads to numerous indeterminate pulmonary nodules for physicians to distinguish too. The value of autoantibody test in risk assessing of IPNs as well as early detection of lung cancer in high risk population has been demonstrated in clinical practice and trial but mainly in Caucasian. Purpose of this study is to understand the sensitivity, specificity and accuracy of candidate autoantibodies, and consequently explore the autoantibody combination with best clinical performance in Chinese population.

Early Cancer Detection Test - Lung Cancer China

Clinic Validation of Autoantibody Panel for Lung Cancer Diagnosis in Chinese Population

The combination which can achieve best sensitivity at 90% specificity, and its sensitivity, accuracy and PPV.

Gene Tech (Shanghai) Company Limited

Bai Chunxue

Chairman

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Early Cancer Detection Test - Lung Cancer China	NCT04216511	Lung Cancer	Tumor autoantib...	18 Years - 100 Years	Chinese Alliance Against Lung Cancer
Early Cancer Detection Test - Lung Cancer China	NCT04216511	Lung Cancer	Tumor autoantib...	18 Years - 100 Years	Chinese Alliance Against Lung Cancer

Spots Global Cancer Trial Database for indeterminate pulmonary nodule