Symptoms and General Pathology

All Conditions

Neoplasms

Blood and Lymph Conditions

Immune System Diseases

Behaviors and Mental Disorders

Rare Diseases

Fatigue

Lymphoma

Leukemia

Lymphoma, Non-Hodgkin

Hematologic Neoplasms

Leukemia, Myeloid

Leukemia, Myeloid, Acute

Hematologic Diseases

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Quality of Life

Lymphosarcoma

Acute Graft Versus Host Disease

Participants who agreed to participate in the study will participate in an individualized 6-month physical activity (PA) program, consisting of 3 periods: initiation (1st month), transition (2nd-3rd months) and autonomy (4th-6th months). It is based on 4 PA modalities:

The supervised PA session in a sterile room or at home once a week during the initiation and transition phases (20-45 min, low-to-moderate intensity, walking, muscle strengthening, balance and flexibility exercises).

The unsupervised PA session in a sterile room or at home once a week during the transition phase and twice a week during the autonomy phase (same as supervised session).

Follow-up by telephone once a month during the autonomy phase (30 min, support to PA).

Continuously wearing an activity tracker throughout the entire program (promotion of walking).

Activities are planned over a period of 6 months to achieve an intervention that meets the key principles of progression, specificity and empowerment.

Individualized physical activity program

Emmanuelle NICOLAS-VIRELIZIER

Older people with cancer differ from younger patients due to the combined effects of aging, comorbidities and cancer treatments on their health. In acute myeloid leukemia (AML) and non-hodgkin lymphoma (NHL), chemotherapy, which is the main treatment, is associated with significant toxicity that negatively affects patients' physical capacities and quality of life, already declining with age and comorbidities. It therefore seems essential to develop and evaluate interventions that can prevent physical and psychosocial decline and its consequences in these populations. However, no studies have evaluated a physical activity (PA) program among these populations, although the absence of risk of implementing PA during intense therapeutic procedures has been confirmed.

OCAPI is an interdisciplinary, prospective, interventional, feasibility study. It is intended to include 20 AML and 20 NHL patients 65 years of age or older at the time of initiation of the first chemotherapy line, with an ECOG \<3, with no contraindications to PA and no history or coexistence of other primary cancer.

Expected results are to demonstrate that a program offering supervised sessions in a sterile room or at home and remote support can enable patients with AML or NHL to perform their daily PA in autonomy. All these results will generate preliminary data before implementing a larger national study.

An Individualized Physical Activity Program in Patients Over 65 Years With Hematologic Malignancies

An Interventional Prospective Study to Test the Feasibility of an Individualized Physical Activity Program in Patients Over 65 Years of Age With Hematologic Malignancies: the OCAPI Project.

Ratio of the number of supervised and unsupervised sessions performed by patients / number of scheduled sessions

Ratio of the number of phone calls performed / number of scheduled calls

Ratio of the number of days wearing the activity tracker / number of days of the program

Ratio of number of patients included / number of eligible patients

Number, type and timing of program-related adverse events

Ratio of the number of patients still in the program / number of patients included in the study

Activities of Daily Living questionnaire (ADL) - scale from 0 to 6, 0=autonomy; 6 = no autonomy

Instrumental activities of Daily Living questionnaire (IADL) - scale from 0 to 4, 0=autonomy; 4 = no autonomy

BMI (weight and height will be combined to report BMI in kg/m\^2)

Mini Nutritional Assessment (MNA) - scale from 0 to 30 points; score\<17=bad nutritional status ; 17 and 23.5=risk of malnutrition ; \>24: adaptednutritional status

Montreal Cognitive Assessment (MoCA) ; scale from 0 to 30; normal if score \>16

Geriatric Depression Scale-15 (GDS-15) ; scale from 0 to 15 ; 0 to 5=normal ; 6 and 9 = high probability of depression ; \> 9 = almost systematic depression

Self-efficacy for exercise scale - This scale has a range of total scores from 0-90. A higher score indicates higher self-efficacy for exercise.

Cumulativ Illness Rating Scale - Geriatric (CIRS-G) ; 14 items ; for each one, score from 0 to 4 : 0=no problem and 4=serious issue

European Organization for Research and Treatment of Cancer core quality of life questionnaire (EORTC QLQ-C30) - scale from 0 to 100

Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) ; score from 0 to 65 ; the higher the score is, the less the patient has fatigue

Godin-Shephard Leisure-Time Physical Activity Questionnaire (GSLTPAQ) ; Godin scale score: \< 14 units: insufficiently active/sedentary ; 14-23: moderately active ; 24 or more : active

Évaluation de la précarité et des inégalités de santé pour les CES (EPICES questionnaire) - scale from 0 to 100, 0= no social vulnerability, 100=max vulnerability, threshold=30

Spots Global Cancer Trial Database for individualized physical activity program