Neoplasms

Digestive System Diseases

All Conditions

Colonic Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Herbal and Botanical

All Drugs and Chemicals

Cola

Optional

In pre-training:

Biopsy performed during the digestive surgery procedure

Final evaluation (minimum 1 day and maximum 7 days after the last training session): biopsy performed in the digestive surgery department.

Muscle biopsies

3 sessions per week for 18 weeks. Duration: 1 hour Training on different strength training machines for the main muscle groups of the lower and upper limbs. The training load will be gradually increased over the sessions.

Muscle Strengthening

fasting blood sample taken at assessments 1, 2, 3 and 4 for patients and assessment 1 for controls

Blood and urine samples

3 sessions per week for 18 weeks. Duration: 1 hour Training on a "classic" pedal bicycle (called an ergocycle). The intensity and duration of the training will be gradually increased over the sessions and according to the patient's abilities.

Aerobic Training

Carried out at least 15 days before surgery

1. st visit:

   * Nutritional assessment
   * Body composition
   * Psychometric tests of quality of life + IPAQ Test
   * VO2pic
2. nd visit:

   * Neuromuscular tests
   * Functional tests

Evaluation 1 pre-surgery

1. st visit:

   * Body composition
   * Nutritional assessment
   * Psychometric tests of quality of life
2. nd visit:

   * neuromuscular tests
   * Functional tests
   * Familiarization with training equipment if patient participates in re-training

Evaluation 2 post-surgery

performed 9 weeks after the beginning of training Identical tests to evaluation 1 + TM6

Intermediate Evaluation 3

Final post-training evaluation 4

Anaïs GOUTERON

Vanessa COTTET

Colon cancer is a real public health problem with more than 46,000 new cases diagnosed per year in France and about 650 cases in Burgundy. Muscle deconditioning (MD), which is characterized by a loss of muscle mass and function, is a frequent consequence in cancer patients and conditions the prognosis. Therefore, it is essential to understand its complex etiology in oncology in order to address the real need for therapeutic countermeasures in clinical practice. DM is a multifactorial process that is exacerbated by therapies. It induces neurogenic and muscular alterations that can profoundly affect patients' quality of life.

Currently, analyses of this phenomenon in oncology have been limited essentially to a global evaluation of physical performance, neglecting the muscular and nervous nature of the adaptations responsible for it.

Most studies analyzing the therapeutic effects of physical activity (PA) have shown numerous physiological and psychological benefits of aerobic exercise. However, this form of PA is still not very effective in preserving muscle mass.

Only muscle strengthening can have an anabolic effect by accelerating the rate of protein synthesis.

Neuromuscular Deconditioning and Reconditioning in Colon Cancer Patients: an APA Muscle Rendorcement Program

Neuromuscular Deconditioning and Reconditioning in Colon Cancer Patients: A Pilot Study of an APA Muscle Rendorcement Program

Tolerance in terms of level of effort and pain will be tested at each session and will condition the continuation or not of the sessions and therefore acceptability

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Neuromuscular Deconditioning and Reconditioning in Colon Cancer Patients: an APA Muscle Rendorcement Program	NCT05099211	Colon Cancer Muscle Strength...	Muscle biopsies Muscle Strength... Blood and urine... Aerobic Trainin... Evaluation 1 pr... Evaluation 2 po... Intermediate Ev... Final post-trai...	18 Years - 80 Years	Centre Hospitalier Universitaire Dijon
Neuromuscular Deconditioning and Reconditioning in Colon Cancer Patients: an APA Muscle Rendorcement Program	NCT05099211	Colon Cancer Muscle Strength...	Muscle biopsies Muscle Strength... Blood and urine... Aerobic Trainin... Evaluation 1 pr... Evaluation 2 po... Intermediate Ev... Final post-trai...	18 Years - 80 Years	Centre Hospitalier Universitaire Dijon

Spots Global Cancer Trial Database for intermediate evaluation 3