Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Rare Diseases

Lung Neoplasms

Lung Diseases

Lung Diseases, Interstitial

Respiration Disorders

Respiratory Tract Diseases

Chronic Graft Versus Host Disease

Yong Chul Lee, MD, phD

Yong Chul Lee, MD, PhD

So Ri Kim, MD, PhD

Aim: To investigate whether ER stress is implicated in the pathogenesis of various pulmonary disorders

Measurement:

1. Unfolded protein responses (UPRs) in blood (PBMCs)of patients

   1. CHOP
   2. GRP 78 and so on
2. Unfolded protein responses (UPRs) in blood (PBMCs)of healthy controls

   1. CHOP
   2. GRP 78 and so on

Endoplasmic Reticulum Stress in Chronic Respiratory Diseases

Endoplasmic Reticulum (ER) Stress in Patients With Various Chronic Pulmonary Diseases

Chonbuk National University

Yong Chul Lee

Immune System Diseases

Symptoms and General Pathology

Infections

Digestive System Diseases

Diseases and Abnormalities at or Before Birth

Blood and Lymph Conditions

Asthma

Hypersensitivity

Fibrosis

Pneumonia

Cystic Fibrosis

Lymphangioleiomyomatosis

Alveolitis, Extrinsic Allergic

Pancreatic Diseases

Gastrointestinal Diseases

Genetic Diseases, Inborn

Infant, Newborn, Diseases

Bronchial Diseases

Lung Diseases, Obstructive

Respiratory Hypersensitivity

Hypersensitivity, Immediate

Communicable Diseases

Respiratory Tract Infections

Lymphangiomyoma

Neoplasms by Histologic Type

Perivascular Epithelioid Cell Neoplasms

Neoplasms, Connective and Soft Tissue

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Hypersensitivity Pneumonitis

Included patients, aged ≥ 18 years, with chronic respiratory diseases: COPD, bronchial asthma, cystic fibrosis, lymphangioleiomyomatosis, hypersensitivity pneumonitis and other interstitial lung diseases.

Intervention: breath analysis using the Compact PTR-MS proton mass spectrometer by Ionicon (Austria); electrocardiogram (ECG) in one lead with an assessment of the pulse wave using a portable cardiac monitor "CardioQvark"; assessment of arterial stiffness using the VaSera VS-1500N Fukuda Denshi device by non-invasive measurement of blood pressure in four limbs with simultaneous recording of electrocardiogram (ECG), phonocardiogram (PCG) and pulse waves on the carotid, femoral arteries, as well as on the arteries of four limbs.

Interventions:

Diagnostic Test: Breath analysis using the Compact PTR-MS proton mass spectrometer; Diagnostic Test: Portable cardiac monitor "CardioQvark"; Diagnostic Test: Assessment of arterial stiffness using the VaSera VS-1500N.

Included subjects, aged ≥ 18 years.

Intervention: breath analysis using the Compact PTR-MS proton mass spectrometer by Ionicon (Austria); electrocardiogram (ECG) in one lead with an assessment of the pulse wave using a portable cardiac monitor "CardioQvark"; assessment of arterial stiffness using the VaSera VS-1500N Fukuda Denshi device by non-invasive measurement of blood pressure in four limbs with simultaneous recording of ECG, phonocardiogram (PCG) and pulse waves on the carotid, femoral arteries, as well as on the arteries of four limbs.

Interventions:

Diagnostic Test: Breath analysis using the Compact PTR-MS proton mass spectrometer; Diagnostic Test: Portable cardiac monitor "CardioQvark"; Diagnostic Test: Assessment of arterial stiffness using the VaSera VS-1500N.

Breath samples will be analyzed with a proton-transfer reaction mass spectrometer (Compact PTR-MS, Ionicon, Austria) to obtain eVOCs profiles listed as ions at various mass-to-charge ratios (m/z).

Breath test using the Compact PTR-TOF-MS

Record an electrocardiogram (ECG) in one lead with an assessment of the pulse wave using a portable cardiac monitor "CardioQvark" (Russia, LLC "L Card" , RU No. RZN 2019/8124 dated February 15, 2019) once. Devices automatically transfer data to the A\&D Connect app paired with it (link). When transferring data, they are completely protected. The data obtained using the application must be sent to the specialists of the research group in a depersonalized form.

Portable cardiac monitor "CardioQvark"

Assessment of arterial stiffness using the VaSera VS-1500N Fukuda Denshi device by non-invasive measurement of blood pressure in four limbs with simultaneous recording of ECG, PCG and pulse waves on the carotid, femoral arteries, as well as on the arteries of four limbs.

Assessment of arterial stiffness using the VaSera VS-1500N

Assessment of cardiovascular disorders using echocardiography and arterial stiffness; comparative noninvasive assessment of volatile organic compound (eVOC) exhale breath patterns in patients with different chronic respiratory diseases with age and gender-matched healthy adults in order to identify a disease-specific exhaled eVOCs profiles and markers of respiratory and cardiovascular disorders.

Evaluating of eVOCs profiles by proton mass spectrometry with a time-of-flight (PTR-TOF) in patients with different chronic respiratory diseases is of great interest for assessing the prognosis and development of severe ventilation and cardiovascular disorders.

The aim of our study is to determine the diagnostic significance of PTR-TOF analysis in patients with chronic respiratory diseases and to identify specific eVOC markers of a severe ventilation and cardiovascular disorders in patients with different chronic respiratory diseases.

Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases

Exhaled Breath Proton Mass Spectrometry and Assessment of Endothelial Dysfunction in Patients With Respiratory Diseases

Exhaled volatile organic compounds (eVOCs) profiles listed as ions at various mass-to-charge ratios (m/z)

Pulse wave velocity, augmentation index, pulse wave type (A, B or C) analysed by a portable cardiac monitor "CardioQvark"

Cardio-ankle vascular index and ankle-brachial index analysed with using the VaSera VS-1500N

Clinical data are assessed via questionaire according to the Modified Medical Research Council (mMRC) Dyspnea Scale, Borg Dyspnea scale, standard examination of respiratory function (spirometry, body plethysmography, diffusion test), echocardiography, CT scan of the chest, if necessary, sputum culture results

I.M. Sechenov First Moscow State Medical University

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Endoplasmic Reticulum Stress in Chronic Respiratory Diseases	NCT01211015	ER Stress, Chronic Airway ... Lung Cancer, Interstitial Lu...		18 Years - 80 Years	Chonbuk National University
Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases	NCT05727852	Chronic Respira... Cystic Fibrosis Lymphangioleiom... Hypersensitivit... Interstitial Lu... COPD Bronchial Asthm...	Breath test usi... Portable cardia... Assessment of a...	18 Years -	I.M. Sechenov First Moscow State Medical University

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