Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Nutritional and Metabolic Diseases

Syndrome

Polycystic Ovary Syndrome

Insulin Resistance

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Hypoglycemic Agents

All Drugs and Chemicals

Insulin

Insulin, Globin Zinc

The subjects will attend for supervised training three sessions per week for 10 weeks (9-12). The strength training program involves dynamic contraction at intensities of 60 - 70 % of 1 repetition maximum (RM) to improve strength and muscle hypertrophy. Each session will contain 8 exercises on the major muscle groups. Each drill consists of 10-12 repetitions (reps) x 3 sets separated by one minute rest between sets.

High intensity interval training (HIT) three times per week. The three weekly supervised HIT sessions will include two 4x4 min interval sessions and one 10x1 min session. The HIT consist of "uphill" treadmill running/walking.

Based on the Norwegian recommendation we will encourage the control group to perform 60 minutes of physical activity at moderate to high intensity on a daily basis.

strength training

interval training

Trine Moholdt, phd

The aim is to investigate whether strength training or high intensity interval training is effective in improving insulin sensitivity, cardiovascular outcomes, body composition and reproductive outcomes in women with Polycystic Ovary Syndrome (PCOS).

Few studies have examined the effect of strength training alone on insulin sensitivity, reproductive outcomes and body composition in women with PCOS. Most previous studies on aerobic exercise in PCOS have applied moderate exercise intensity.

High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome

High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome. A Randomized Controlled Trial

measured with the homeostatic model assessment for insulin resistance (HOMA-IR) method

Measured as body fat % on an impedance scale and waist circumference

Measured during maximum effort exercise test

Flow mediated dilatation of the brachial artery.

Norwegian University of Science and Technology

Digestive System Diseases

Rare Diseases

Neoplasm Metastasis

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Primary Liver Cancer

Hematinics

Liver Extracts

Patients in experimental group will perform a 6 weeks' physical activity program with 3 sessions per week. Physical activity intervention will consist in 2 different interval training programs on cycloergometer: Interval training 1 and Interval training 2, with a difference in exercise intensities.

Interval training

Patients in control group will follow the standard oncologic care. They will perform only 2 sub-maximal exercises.

Standard Oncologic care

The aim of this study is to assess the impact of preoperative physical activity on physical capacities of patients undergoing liver resection for primary or secondary liver cancer.

The purpose of this study is to investigate the effects of a preoperative exercise program in patients with primary or secondary liver cancer undergoing hepatectomy. Preoperative exercise programs have been shown to be effective in other cancer populations, but have been poorly studied in patients with liver cancer. For these patients, it remains unclear what the optimal composition of such programs should be and how they should be delivered. Outcome measures in this study will include preoperative outcomes (oxygen consumption, quality of life, fatigue and physical activity level, anthropometric measures, plasma concentrations of hepatokines) and postoperative outcomes (length of hospital stay and postoperative complications).

After the study is explained and consent obtained, subjects will be tested on a submaximal exercise on cycloergometer with gas exchanges analysis and with pre and post blood test. Then, they will answer various questionnaires assessing physical activity, quality of life and fatigue.

Patients scheduled for liver resection will be randomized to one of two groups. The first group (experimental group) will be subdivided into two groups: interval training 1 and interval training 2, which differentiate themselves by two different intensities.The second group (control group) will receive standard care.

The prehabilitation program will last 6 weeks with 3 sessions per week and will consist in two interval training programs on a cycloergometer with two different intensities.

One month after surgery, peri and postoperative complications will be noted.

Preoperative Physical Activity Intervention in Patients Before Planned Liver Resection for Cancer (APACHE)

Preoperative Physical Activity Intervention in Patients Before Planned Liver Resection for Cancer

Oxygen consumption at anaerobic threshold will be assessed at baseline and at the end of the 6 weeks' program with a submaximal exercise performed on cycloergometer

Postoperative complications will be assessed using the Dindo Clavien classification which consists in a 7 grades classification (I, II, IIIa, IIIb, IVa, IVb and V).

Postoperative intensive care stay will be evaluated (number of days).

Fetuin A (ng/mL) concentrations will be analyzed.

Fibroblast Growth Factor 21 (FGF21) (pg/mL) concentrations will be analyzed.

Physical activity level will be measured using the long-form of the International Physical Activity Questionnaire (IPAQ). It consist in a description of the physical activity level by assessing 5 activity domains during the 7 last days. Physical activity level is expressed in Metabolic Equivalent Tasks (METs). It enables to classify patients in 3 categories : low physical activity level, moderate physical activity level and high physical activity level.

Health related quality of life will be measured with the EORTC Quality of Life Questionnaire QLQ-C30 which is a cancer specific questionnaire. It consists in 30 items to measure 15 dimensions of quality of life. It generates a score between 0 and 100. A higher score means a higher quality of life level.

Fatigue will be measured with the Quality of Life Questionnaire QLQ-FA12 which enables to assess cancer related fatigue. It consists in 12 items to measure 5 dimension go health related fatigue. It generates a score between 0 and 100. A higher score means a higher fatigue level.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome	NCT01919281	Polycystic Ovar...	strength traini... interval traini...	18 Years - 45 Years	Norwegian University of Science and Technology
High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome	NCT01919281	Polycystic Ovar...	strength traini... interval traini...	18 Years - 45 Years	Norwegian University of Science and Technology
High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome	NCT01919281	Polycystic Ovar...	strength traini... interval traini...	18 Years - 45 Years	Norwegian University of Science and Technology
Preoperative Physical Activity Intervention in Patients Before Planned Liver Resection for Cancer (APACHE)	NCT03518632	Primary Liver C... Secondary Liver... Liver Metastase...	Interval traini... Standard Oncolo...	18 Years -	Centre Hospitalier Universitaire de Besancon
High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome	NCT01919281	Polycystic Ovar...	strength traini... interval traini...	18 Years - 45 Years	Norwegian University of Science and Technology

Spots Global Cancer Trial Database for interval training