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Direct intrabone transplantation procedure of peripheral blood haematopoietic stem cells form HLA-matched sibling donors in patients with myeloid and lymphoid malignancies.

Intrabone transplantation

Tomasz Czerw, MD

Sebastian Giebel, MD

Sebastian Giebel, Assoc. prof.

The purpose of the study is to evaluate efficacy and safety of direct intrabone transplantation procedure of peripheral blood haematopoietic stem cells form HLA-matched sibling donors in patients with myeloid and lymphoid malignancies.

Allogenic haematopoietic stem cell transplantation is an established treatment option for haematologic malignancies, especially leukaemias and lymphomas, providing curative potential. The optimal donor is HLA-matched sibling and G-CSF stimulated peripheral blood is nowadays the most common source of stem cells. Routinely used route of stem cell transplantation is intravenous infusion via central venous catheter. Based on the animal studies, only 10-15% of intravenously transplanted stem cells migrate to haematopoietic sites while the rest is lost in other organs. Results of studies of direct intrabone allogenic cord-blood cells transplantation in humans confirm that this route of transplantation is associated with less probability of graft failure and moreover may reduce risk of graft-versus-host disease and malignancy relapse. For those purposes in the current study we investigate intrabone route of allogenic peripheral blood stem cell transplantation. Our intention is to achieve fast engraftment and minimize risk of relapse and graft graft-versus-host disease.

Intrabone Transplantation of Allogenic Peripheral Blood Stem Cells in Patients With Myeloid and Lymphoid Malignancies.

Efficacy and Safety of Direct Intrabone Transplantation of Peripheral Blood Haematopoietic Stem Cells Form HLA-matched Sibling Donors in Patients With Myeloid and Lymphoid Malignancies.

Maria Sklodowska-Curie National Research Institute of Oncology

Hematologic Neoplasms

Patients with high risk haematological malignancies

Unrelated single unit intrabone cord blood transplantation

Intrabone Allogeneic Transplant

Roberto Sorasio, Head, MD

Daniele Mattei, MD

Roberto Sorasio, MD

Cord blood (CB) from an unrelated donor is increasingly used an alternative source of hematopoietic stem cells for adults with hematologic malignancies who lack an HLA-matched donor. However, the utilization of single-unit CB for transplantation of adult patients has been impeded by the low number of nucleated cells available from individual CB units. Direct intrabone CB injection (IBCBi) has been recently investigated as a solution to cell dose problem in adults, with the aims of minimizing non-specific loss of progenitors. We set up a phase I-II study to assess the safety and efficacy of CB transplantation by IBCBi in adult patients with advanced or high-risk hematological malignancies

Intra-bone Cord Blood Transplantation in Patients With Haematological Malignancies

Ospedale Santa Croce-Carle Cuneo

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Intrabone Transplantation of Allogenic Peripheral Blood Stem Cells in Patients With Myeloid and Lymphoid Malignancies.	NCT01728389	Leukemia Lymphoma	Intrabone trans...	18 Years - 55 Years	Maria Sklodowska-Curie National Research Institute of Oncology
Intrabone Transplantation of Allogenic Peripheral Blood Stem Cells in Patients With Myeloid and Lymphoid Malignancies.	NCT01728389	Leukemia Lymphoma	Intrabone trans...	18 Years - 55 Years	Maria Sklodowska-Curie National Research Institute of Oncology
Intra-bone Cord Blood Transplantation in Patients With Haematological Malignancies	NCT01613066	High Risk Haema... Advanced Haemat...	Intrabone Allog...	18 Years - 65 Years	Ospedale Santa Croce-Carle Cuneo

Spots Global Cancer Trial Database for intrabone

Every month we try and update this database with for intrabone cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for intrabone

Every month we try and update this database with for intrabone cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for intrabone cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.