Spots Global Cancer Trial Database for Intra-bone Cord Blood Transplantation in Patients With Haematological Malignancies
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Trial Identification
Brief Title: Intra-bone Cord Blood Transplantation in Patients With Haematological Malignancies
Official Title: Intra-bone Cord Blood Transplantation in Patients With Haematological Malignancies
Study ID: NCT01613066
Interventions
Study Description
Brief Summary: Cord blood (CB) from an unrelated donor is increasingly used an alternative source of hematopoietic stem cells for adults with hematologic malignancies who lack an HLA-matched donor. However, the utilization of single-unit CB for transplantation of adult patients has been impeded by the low number of nucleated cells available from individual CB units. Direct intrabone CB injection (IBCBi) has been recently investigated as a solution to cell dose problem in adults, with the aims of minimizing non-specific loss of progenitors. We set up a phase I-II study to assess the safety and efficacy of CB transplantation by IBCBi in adult patients with advanced or high-risk hematological malignancies
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Azienda Ospedaliera S Croce e Carle, Cuneo, , Italy
Contact Details
Name: Daniele Mattei, MD
Affiliation: ASO S Croce e Carle
Role: PRINCIPAL_INVESTIGATOR
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