Symptoms and General Pathology

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

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Gland and Hormone Related Diseases

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Infertility

Polycystic Ovary Syndrome

Genital Diseases

Urogenital Diseases

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Ovarian Diseases

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Genital Diseases, Female

Female Urogenital Diseases

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Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Anticoagulants

All Drugs and Chemicals

Reproductive Control Agents

Bone Density Conservation Agents

Other Dietary Supplements

Citric Acid

Sodium Citrate

Ethinyl Estradiol

Estradiol 17 beta-cypionate

Estradiol 3-benzoate

Estradiol

Polyestradiol phosphate

Clomiphene

Enclomiphene

Zuclomiphene

Calcium

Calcium, Dietary

Chelating Agents

Estrogens

Estrogen Antagonists

Estrogen Receptor Antagonists

Hormones

Hormone Antagonists

Estrogen Receptor Modulators

Selective Estrogen Receptor Modulators

Citrate

Clomiphene citrate is used in combination of ethinyl estradiol (0.05 mg for 5 days) for induction ovulation of polycystic ovary syndrome women undergoing intrauterine insemination

Clomiphene citrate is used in combination of placebo (for 5 days) for induction ovulation of polycystic ovary syndrome women undergoing intrauterine insemination

clomiphene citrate with ethinyl esteradiol

clomiphene citrate with plasebo

hamid gourabi, PhD

Ashraf Moieni, MD

According to the studies CC is successful at inducing ovulation in 50%-75% of cases, but only 30-40% becomes pregnant. The difference has been attributed to a negative action of clomifen citrate(CC) in the form of prolonged antiestrogenic effects on endometrial receptivity. For avoiding of these negative effects, giving ethinyl estradiol in sufficient dosages may be effective. The purpose of this study is comparing pregnancy rates after IUI in women who use CC alone and those who use CC in combination with ethinyl estradiol

The proposal of This study approved by our institutional review boards and institution's ethical committee, and all Participants will sign a written consent before enter to study. All patients will be randomly divided into two groups, A and B. Stimulation will begin on day 3 with the administration of 100 mg of clomifen citrate(CC) daily for 5 days. On day 8, ethinyl estradiol will be given daily for 5 days in group A and placebo will be given for 5 days in group B. Plasma levels of estradiol(E2), Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) will be evaluated on days 3 and 13 of the menstrual cycle. Ultrasound examination will be done on days 3, 13 and days of HCG administration and IUI for determining of endometrial thickness, number of follicles and size of the dominant follicle.

When the diameter of at least one follicle reached equal or greater than 18 mm, human chronic gonadotrophin (HCG) 10,000 IU will be administered.

The pulsatility index also will be recorded in both uterine arteries on day of HCG administration. A single IUI will be performed 24-36 hours after the administration of hCG. Pregnancy will be confirmed by increasing level of concentration of serum βHCG which will be assessed 14 days after IUI

The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination

Evaluate the Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination

Usage of clomifen citrate on special days can increase pregnancy rate

usage of clomiphen citrate with ethyl estradiol in patients with poly cystic ovary can stimulate ovulation

effect of using drugs to increase endometrial thickness

Royan Institute

highly purified urinary FSH

timed intercourses, intrauterine insemination

Stefano Palomba, MD

Francesco Orio, MD

Achille Tolino, MD

At the present the first options to induce ovulation in polycystic ovary syndrome with anovulatory infertility are clomiphene citrate (CC) and metformin. Notwithstanding the effectiveness of CC and metformin alone or in a sequential or combined regimen, a percentage of patients ranging from 5% to 30% remain anovulatory. For these patients, the use of gonadotropins for controlled ovarian stimulation (COS) is indicated.

Moreover, to date it isn't clear if COS should be followed by timed intercourse (TI) or intrauterine insemination (IUI).

The aim of the present study will be to compare TI and IUI in infertile PCOS patients undergoing COS in terms of cost-benefit.

Infertile PCOS patients who remain anovulatory after CC or metformin treatment will be enrolled. All patients will receive gonadotropins in low-dose step-up protocol for COS, and randomized to receive three trials of TI (group A) or IUI (group B).

All patients eligible will undergo baseline assessment consisting of anthropometric, hormonal, and ultrasonographic evaluations.

In all patients the COS will be obtained using highly purified urinary FSH in a low-dose step-up protocol, and both TI and IUI will be performed after 35 hours from ovulation induction with human chorionic gonadotropin.

During the study, the clinical and reproductive outcomes, the adverse experience will be evaluated in each patient.

Data will be analyzed using the intention-to-treat principle and a P value of 0.05 or less will be considered significant. Continuous variables will be analyzed with the unpaired t test and general linear model for repeated measures analysis with Bonferroni test for the post-hoc analysis as required. For categorical variables, the Pearson chi-square and Fisher's exact tests will be used. Cumulative pregnancy rate, our primary end-point, will be calculated by the Kaplan-Maier method, and the differences between the two groups will be assessed with the log-rank test. Cox proportional-hazards model will be used to calculate the hazard ratio for new pregnancy in both groups.

Controlled Ovarian Stimulation Followed by Timed Intercourse or Intrauterine Insemination in Infertile PCOS Patients

Timed Intercourse Versus Intrauterine Insemination in Infertile Patients Undergoing Gonadotropin Ovarian Stimulation

University Magna Graecia

Associate Professor

controlled ovarian hyperstimulation (COH) and intrauterine insemination (IUI)

Controlled ovarian hyperstimulation (COH)+ Timed Intercourse (TI)

The male semen is obtained then processed by swim up technique and then introduced into the uterus by special catheter.

Intrauterine insemination (IUI)

Ahmed Gibreel, MD

The study null hypothethesis is: intrauterine insemination (IUI) does not improve pregnancy rates in women with polycystic ovary syndrome. Infertile women with pcos will receive gonadotropins for ovarian stimulation and then randomize to either IUI or timed intercourse (TI)

Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome

Mansoura University

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination	NCT01219101	Infertility	clomiphene citr... clomiphene citr...	25 Years - 30 Years	Royan Institute
Controlled Ovarian Stimulation Followed by Timed Intercourse or Intrauterine Insemination in Infertile PCOS Patients	NCT00502281	Polycystic Ovar...	highly purified... timed intercour...	18 Years - 35 Years	University Magna Graecia
Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome	NCT01675843	Infertility Polycystic Ovar... Intrauterine In...	Intrauterine in...	21 Years - 38 Years	Mansoura University
Controlled Ovarian Stimulation Followed by Timed Intercourse or Intrauterine Insemination in Infertile PCOS Patients	NCT00502281	Polycystic Ovar...	highly purified... timed intercour...	18 Years - 35 Years	University Magna Graecia
Controlled Ovarian Stimulation Followed by Timed Intercourse or Intrauterine Insemination in Infertile PCOS Patients	NCT00502281	Polycystic Ovar...	highly purified... timed intercour...	18 Years - 35 Years	University Magna Graecia
The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination	NCT01219101	Infertility	clomiphene citr... clomiphene citr...	25 Years - 30 Years	Royan Institute
Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome	NCT01675843	Infertility Polycystic Ovar... Intrauterine In...	Intrauterine in...	21 Years - 38 Years	Mansoura University
Controlled Ovarian Stimulation Followed by Timed Intercourse or Intrauterine Insemination in Infertile PCOS Patients	NCT00502281	Polycystic Ovar...	highly purified... timed intercour...	18 Years - 35 Years	University Magna Graecia

Spots Global Cancer Trial Database for intrauterine insemination