Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Skin and Connective Tissue Diseases

Symptoms and General Pathology

Digestive System Diseases

Gland and Hormone Related Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Rare Diseases

Carcinoma, Non-Small-Cell Lung

Breast Neoplasms

Neoplasm Metastasis

Carcinoma

Carcinoma, Squamous Cell

Lung Neoplasms

Pancreatic Neoplasms

Sarcoma

Adenocarcinoma

Urinary Bladder Neoplasms

Melanoma

Carcinoma, Renal Cell

Carcinoma, Lobular

Carcinoma, Ductal, Breast

Gastrointestinal Neoplasms

Digestive System Neoplasms

Neoplasms, Squamous Cell

Carcinoma, Ductal

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms, Nerve Tissue

Nevus, Pigmented

Nevus

Nevi and Melanomas

Skin Neoplasms

Skin Diseases

Endocrine Gland Neoplasms

Gastrointestinal Diseases

Pancreatic Diseases

Endocrine System Diseases

Neoplasms, Connective and Soft Tissue

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Male Urogenital Diseases

Kidney Neoplasms

Kidney Diseases

Breast Diseases

Pancreatic Cancer

Soft Tissue Sarcoma

Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Neuroendocrine Tumor

Neuroepithelioma

Participants will have metastatic solid tumors and at least two sites of measurable extra-cranial disease

The primary site requiring palliative radiotherapy will receive conventional SBRT dosing of SBRT (or an alternate standard-of-care schedule).

Stereotactic body radiotherapy

A second metastatic site (GTV volume at least 100 cc) will receive elective palliation with a lattice RT pattern (LRT).

Lattice Radiation Therapy

Atif Khan, MD

Christopher Barker, MD

The purpose of this study is to find out whether lattice radiation therapy (LRT) is an effective radiation therapy technique when compared to standard stereotactic body radiation therapy (SBRT). The study will also study how the different radiation therapy techniques (LRT and SBRT) affect how many immune cells are able to attack and kill tumor cells (immune infiltration).

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

A Pilot Study of Spatially Fractionated Radiation Therapy in Patients With Extra-Cranial Soft Tissue Metastases

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

The primary endpoint is ORR in the LRT-treated lesion, as defined by RECIST v.1.1 criteria, at 12 weeks on a standard-of-care response assessment CT or F-18-FDG PET/CT scan after LRT.

Varian Medical Systems

Memorial Sloan Kettering Cancer Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue	NCT05837767	Invasive Ductal... Invasive Ductal... Lobular Breast ... Lobular Breast ... Non Small Cell ... NSCLC Gastrointestina... Gastrointestina... Gastrointestina... Pancreatic Canc... Bladder Cancer Renal Cell Carc... Melanoma Sarcoma Metastatic Soli...	Stereotactic bo... Lattice Radiati...	18 Years -	Memorial Sloan Kettering Cancer Center
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue	NCT05837767	Invasive Ductal... Invasive Ductal... Lobular Breast ... Lobular Breast ... Non Small Cell ... NSCLC Gastrointestina... Gastrointestina... Gastrointestina... Pancreatic Canc... Bladder Cancer Renal Cell Carc... Melanoma Sarcoma Metastatic Soli...	Stereotactic bo... Lattice Radiati...	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for invasive ductal breast carcinoma stage iv