Nutritional and Metabolic Diseases

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Malnutrition

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Gastrointestinal Diseases

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Receive iPLANT diet plan and diet counselling by a qualified dietitian in oncology setting.

A diet plan which mainly consists of plant-based food will be designed based on participants' energy and protein needs. The counselling covers (1) guidance to achieve energy and protein requirement (2) advice on food to be included in iPLANT diet plan (Mediterranean diet: increase intake of fish and legumes; moderate intake of eggs, dairy, nuts, poultry; limit intake of red meat).

iPLANT diet plan and diet counselling

General dietary advices on how to improve oral intake and maintain healthy weight will be provided.

Usual diet counselling

SHIN LU NG, master

SHIN LU NG

The goal of this intervention study is to investigate the effectiveness of individualized plant-based diet plan on nutritional indices and clinical outcomes in colorectal cancer patients receiving chemotherapy. The main questions to answer are:

1. What are the current eating trends in colorectal cancer patients?
2. What are the common perceptions of adopting a plant-based diet in colorectal cancer?
3. Does iPLANT diet plan improve nutritional indices of colorectal cancer patients?
4. Does iPLANT diet plan improve patients' gastrointestinal side effects and quality of life without compromising their nutritional status?

Participants will be randomly assigned into two arms (intervention and control) using opaque envelop system. Intervention group will receive individualized plant-based diet plan and diet counselling, whereas the control group will receive usual diet counselling.

The researcher will compare the differences in nutritional outcomes and quality of life between intervention and control groups before and after intervention.

Feasibility, Acceptability, and Effectiveness of an Individualized Plant-based (iPLANT) Diet Plan in Colorectal Cancer: Mixed Method Embedded Design

The Prognostic Nutritional Index is used to assess the nutritional status. Respondents are severely malnourished if score less than 40

Higher score indicates higher level of inflammation

The PG-SGA score is derived from components of weight history, food intake, nutritional impact symptoms, and activity function. The possible scores range from 0 (well-nourished) to 37 (worst possible malnourished)

The higher values of skeletal muscle index and phase angle indicate lower risk of malnutrition, whereas higher reading of extracellular water ratio indicates higher risk of malnutrition. Higher body fat mass indicates higher adiposity level.

Respondents develop cachexia if values are less than 32 (male) and 18 (female)

Respondents have weak muscle if the values are 27 or less (male) and 16 or less (female)

EORTC QLQ-CR29 is a validated tool to measure the functional scales and symptomatic level of colorectal cancer that resulted from disease or treatment factors. Possible scores range from 0 to 100, which higher score indicates better functional scale or worse symptomatic level

Higher intake of daily energy and protein indicates improved oral intake

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Feasibility, Acceptability, and Effectiveness of an Individualized Plant-based (iPLANT) Diet Plan in Colorectal Cancer: Mixed Method Embedded Design	NCT06250166	Colorectal Canc... Nutrition Poor Gastrointestina... Quality of Life	iPLANT diet pla... Usual diet coun...	18 Years -	National Cancer Institute, Malaysia
Feasibility, Acceptability, and Effectiveness of an Individualized Plant-based (iPLANT) Diet Plan in Colorectal Cancer: Mixed Method Embedded Design	NCT06250166	Colorectal Canc... Nutrition Poor Gastrointestina... Quality of Life	iPLANT diet pla... Usual diet coun...	18 Years -	National Cancer Institute, Malaysia

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