Neoplasms

All Conditions

Digestive System Diseases

Adenocarcinoma

Crohn Disease

Intestinal Diseases

Inflammatory Bowel Diseases

Gastroenteritis

Gastrointestinal Diseases

endoscopic enteroscopy to do biopsies on jejunum

enteroscopy

Marion Simon, Doctor

Marc Lémann, PhD

Yoram BOUHNIK, PhD

Patients with Crohn's disease (CD) have an increased risk of small bowel adenocarcinoma (SBA). Long duration of CD is the main risk factor. SB dysplasia has been associated with SBA in 20% of cases, always described in diseased sites. The progression to neoplasia and natural history remains unknown but progression of inflammation to dysplasia and then to adenocarcinoma is suspected.

As for surveillance recommendations for colorectal carcinoma in long standing inflammatory colonic disease, endoscopic screening of SB could be proposed in CD patients with risk factors of SBA. No study can be found in literature.

The investigators propose a multicenter exploratory open study on prospective cohort of CD patients with high risk of dysplasia or cancer. The goal is evaluate the rate of dysplasia and adenocarcinoma detected by enteroscopy with biopsies in a high risk CD population

Endoscopic Detection of Dysplasia in Crohn 's Disease Patient

Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients

dysplasia will be described as high or low level Samples will be analysed by 2 different team of anapathologists

the success will be measured by reaching at least one pathologic area during the endoscopic procedure

Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives

Symptoms and General Pathology

Rare Diseases

Recurrence

Gastrointestinal Stromal Tumors

Disease Attributes

Antineoplastic Agents

All Drugs and Chemicals

Imatinib Mesylate

The series comprises 77 patients, of which 29 (37.7%) were located in the jejunum or ileum (JI-GIST).

The series comprises 77 patients, of which 48 (62.3%) were located in the stomach (G-GIST).

Introduction: Gastrointestinal Stromal Tumors (GISTs) located in the jejunum or ileum (JI-GIST) are considered of worse prognosis compared to other locations. It has been suggested that this dogma should be revised. The aim of this study is to describe the characteristics of jejunoileal GISTs and its prognosis; and to compare them with gastric GISTs in the era of imatinib.

Patients and methods: We retrospectively reviewed the clinical histories of all the patients diagnosed with GISTs between January 2000 and November 2016. Clinical and pathological data, as well recurrence, metastatic, disease-free survival (DFS) as overall (OS) rates of patients with JI-GIST or gastric GIST (G-GIST) were collected and compared.

Jejunoileal vs Gastric GIST in the Era of Imatinib.

Characteristics and Prognosis of Jejunoileal Gastrointestinal Stromal Tumors (GISTs) in the Era of Imatinib. A Comparative Retrospective Study With Gastric GISTs.

Number of patients with a molecular analysis positive for KIT mutation

Number of patients with a molecular analysis positive for PDGFRA mutation

Number of patients with immunohistochemical expression of CD117

Number of patients with immunohistochemical expression of DOG1

Number of patients with recurrence after treatment with tyrosinkin inhibitors.

Number of patients deceased during follow-up.

Location of the tumor (gastric o jejunoileal)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Endoscopic Detection of Dysplasia in Crohn 's Disease Patient	NCT01180452	Crohn Disease L...	enteroscopy	18 Years -	Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Jejunoileal vs Gastric GIST in the Era of Imatinib.	NCT03923400	Disease-free Su... Overall Surviva... Recurrence		18 Years -	Hospital Universitario Virgen de la Arrixaca

Spots Global Cancer Trial Database for jejunum

Every month we try and update this database with for jejunum cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for jejunum

Every month we try and update this database with for jejunum cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for jejunum cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.