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Brief Title: Endoscopic Detection of Dysplasia in Crohn 's Disease Patient
Official Title: Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients
Study ID: NCT01180452
Brief Summary: Patients with Crohn's disease (CD) have an increased risk of small bowel adenocarcinoma (SBA). Long duration of CD is the main risk factor. SB dysplasia has been associated with SBA in 20% of cases, always described in diseased sites. The progression to neoplasia and natural history remains unknown but progression of inflammation to dysplasia and then to adenocarcinoma is suspected. As for surveillance recommendations for colorectal carcinoma in long standing inflammatory colonic disease, endoscopic screening of SB could be proposed in CD patients with risk factors of SBA. No study can be found in literature. The investigators propose a multicenter exploratory open study on prospective cohort of CD patients with high risk of dysplasia or cancer. The goal is evaluate the rate of dysplasia and adenocarcinoma detected by enteroscopy with biopsies in a high risk CD population
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Chu Amiens, Amiens, , France
Chu Besancon, Besancon, , France
Hopital Beaujon, Clichy, , France
Hopital Bicetre, Le Kremlin Bicetre, , France
Chru Lille, Lille, , France
CHU NICE, Nice, , France
Hopital Saint Louis, Paris, , France
Institut Mutualiste Montsouris (Imm), Paris, , France
Hopital Haut Leveque, Pessac, , France
CHU LYON, Pierre Benite, , France
Chu Rouen, Rouen, , France
Chu Saint Etienne, St Etienne, , France
Chu Toulouse, Toulouse, , France
Chu Tours, Tours, , France
Chu Nancy, Vandoeuvre Les Nancy, , France
Name: Marion Simon, Doctor
Affiliation: Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Role: PRINCIPAL_INVESTIGATOR
Name: Marc Lémann, PhD
Affiliation: Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Role: STUDY_CHAIR
Name: Yoram BOUHNIK, PhD
Affiliation: Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Role: STUDY_DIRECTOR