Blood and Lymph Conditions

Nutritional and Metabolic Diseases

All Conditions

Symptoms and General Pathology

Neoplasms

Digestive System Diseases

Anemia, Iron-Deficiency

Iron Deficiencies

Postoperative Complications

Anemia

Colorectal Neoplasms

Deficiency Diseases

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Hematologic Diseases

Metabolic Diseases

Iron Metabolism Disorders

Anemia, Hypochromic

Malnutrition

Nutrition Disorders

Anti-Inflammatory Agents

Antirheumatic Agents

Analgesics

All Drugs and Chemicals

Micronutrients

Anti-Infective Agents

Chrysarobin

Iron

Anti-Bacterial Agents

Antibiotics, Antitubercular

Defined as: decreased serum iron concentration and TSAT, increased TIBC, UIBC, as well as decreased haemoglobin concentration (HGB)

Defined as: decreased serum iron concentration and TSAT, increased TIBC, UIBC, as well as normal HGB

Defined as: normal serum iron concentration, TSAT, TIBC, UIBC and HGB

Erythrocyte indices based on the preoperative complete blood count results will be calculated for each patient one day prior to surgical treatment.

Overall morbidity of each patient during hospital stay will be scored using the Comprehensive Complication Index (CCI). Intraoperative complications will be graded according to the ClassIntra classification of intraoperative adverse events. The quality of postoperative recovery of each observed patient will be scored on the first, second and fifth postoperative day, using the 15-item quality of recovery scale (QoR-15).

Data about red blood cell transfusion rate, all-cause infection rate, number of days when antibiotics were administered and the number of different antibiotics administered during hospital-stay will be collected.

Laboratory analyses for the detection of iron deficiency anaemia

Nora Mihalek, MD

Dragana Radovanovic, Prof. Dr.

The aim of this prospective, observational cohort study is to assess the impact of iron deficiency anaemia on the incidence of perioperative complications and the quality of recovery after surgery in patients undergoing colorectal cancer surgery. The main questions the study aims to answer are:

* whether the presence of preoperative iron deficiency anaemia leads to a poorer quality of postoperative recovery in patients undergoing colorectal cancer surgery
* whether different combinations of complete blood count parameters (red blood cell indices) could be suitable diagnostic tools for the detection of iron deficiency in the latent stage (without laboratory-confirmed anaemia) in colorectal cancer patients.

Blood samples for laboratory analyses will be collected from each study patient admitted to the surgical ward one day prior to elective surgery and on the first postoperative day during the stay in the intensive care unit. The pre-operative laboratory analyses include a complete blood count and serum iron status parameters (iron concentration, ferritin concentration, TIBC, UIBC and TSAT). Laboratory parameters analysed on the first postoperative day include complete blood count, serum concentration of electrolytes (Na, K, Ca, Cl, Mg), serum concentration of urea and creatinine, parameters of haemostasis (aPTT, PT, INR), serum concentration of C-reactive protein and procalcitonin.

Data about overall morbidity, intraoperative complications, quality of postoperative recovery, red blood cell transfusion rate, all-cause infection rate, antibiotic usage, as well as length of hospital stay will be collected.

The researchers will compare the group of patients with iron deficiency anaemia, the group of patients with iron deficiency in the latent stage and the control group to determine whether patients with iron deficiency have a higher incidence of perioperative complications and impaired recovery after surgery. The researchers will investigate whether iron deficiency can be detected at an early stage, when anaemia is not yet present, by calculating various red blood cell indices.

The following erythrocyte indices based on the preoperative complete blood count results will be calculated for each patient one day prior to surgical treatment:

* Mentzer index: MCV / RBC
* Green and King index: MCV2 x RDW / (100 x HGB)
* RDW index: MCV x RDW / RBC
* Shine and Lal index: MCV2 x MCH / 100
* England and Fraser index: MCV - RBC - (5 x HGB) - 3.4
* Srivastava index: MCH / RBC
* Ricerca index: RDW / RBC
* Ehsani index: MCV - (10 x RBC)
* Sirdah index: MCV - RBC - (3 x HGB)
* Sehgal index: MCV2 / RBC

The Ganzoni equation for calculating total iron deficit will be calculated for each patient one day prior to surgical treatment, using the following formula:

total iron deficit \[mg\] = body weight \[kg\] x (target hemoglobin \[g/L\] - actual hemoglobin \[g/L\]) x 2.4 + iron depot \[mg\]

Iron-deficiency Anaemia and Its Impact on Recovery After Colorectal Cancer Surgery

Preoperative Evaluation and Impact of Iron Deficiency Anaemia on the Incidence of Perioperative Complications and Quality of Recovery After Radical Colorectal Cancer Surgery

score of Comprehensive Complication Index (CCI)

grade of ClassIntra classification of intraoperative adverse events

calculated based on the complete blood count parameters

University of Bern

Oncology Institute of Vojvodina

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Iron-deficiency Anaemia and Its Impact on Recovery After Colorectal Cancer Surgery	NCT06276140	Iron Deficienci... Iron Deficiency... Postoperative C... Colorectal Canc...	Laboratory anal...	18 Years -	Oncology Institute of Vojvodina
Iron-deficiency Anaemia and Its Impact on Recovery After Colorectal Cancer Surgery	NCT06276140	Iron Deficienci... Iron Deficiency... Postoperative C... Colorectal Canc...	Laboratory anal...	18 Years -	Oncology Institute of Vojvodina

Spots Global Cancer Trial Database for laboratory analyses for the detection of iron deficiency anaemia