Infections

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Immune System Diseases

COVID-19

Communicable Diseases

Acquired Immunodeficiency Syndrome

HIV Infections

Pneumonia

Pneumonia, Viral

Respiratory Tract Infections

Virus Diseases

Coronavirus Infections

Coronaviridae Infections

Nidovirales Infections

RNA Virus Infections

Lung Diseases

Respiratory Tract Diseases

All Drugs and Chemicals

Antibodies

Antibodies, Monoclonal

Vaccines

Immunoglobulins

Immunoglobulins, Intravenous

gamma-Globulins

Rho(D) Immune Globulin

1. After full vaccination with a Covid 19 vaccine, the following laboratory samples will be taken one time only, two weeks after full dose vaccination: i. Serologic rapid test (IgG, IgM) ii. Serum quantitative immunoglobulin levels iii. CD4 level iv. CD8 level
2. Laboratory samples will be taken at Hospital Auxilio Mutuo Laboratorio Clínico. Likewise, the Immuno Reference Lab might be used as an alternative.
3. Since monoclonal antibody therapy can induce hypogammaglobulinemia, we will measure gammaglobulin levels to correlate with antibody response to vaccine. Similarly, we will evaluate the CD4 and CD8 counts.

Laboratory Samples

Fernando Cabanillas, MD

Carmen Morales

Javier Morales, MD

Josselyn Molina, MD

This is a Phase II study designed to investigate if the Covid 19 vaccines are capable of eliciting production of antibodies against S protein of Sar-S-Cov-2 virus among patients with medical history of cancer previously treated with monoclonal anti CD-20 antibodies. The antibody production is defined based on the detection of antibodies in the serologic Covid-19 rapid test against S protein or with semiquantitative assay when it becomes available.

Antibodies Production After Covid-19 Vaccination Among Patients With Medical History of Cancer and Anti-CD-20 Treatment

To determine if patients with cancer history or HIV positivity previously treated with monoclonal anti CD-20 are able to produce antibodies after Covid-19 vaccination.

a. Antibody Production defined as: 1. Positive serologic Covid-19 antibodies rapid test against S protein.

Evaluate the Correlation of immunoglobulin levels and the development of Covid-19 antibodies.

Evaluate the correlation of CD4/CD8 counts with the development of Covid-19 antibodies.

Auxilio Mutuo Cancer Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Antibodies Production After Covid-19 Vaccination Among Patients With Medical History of Cancer and Anti-CD-20 Treatment	NCT04779996	Covid19 Cancer HIV Infections	Laboratory Samp...	21 Years -	Auxilio Mutuo Cancer Center
Antibodies Production After Covid-19 Vaccination Among Patients With Medical History of Cancer and Anti-CD-20 Treatment	NCT04779996	Covid19 Cancer HIV Infections	Laboratory Samp...	21 Years -	Auxilio Mutuo Cancer Center

Spots Global Cancer Trial Database for laboratory samples