Digestive System Diseases

All Conditions

Neoplasms

Ear, Nose, and Throat Diseases

Symptoms and General Pathology

Gastroesophageal Reflux

Barrett Esophagus

Esophagitis

Esophagitis, Peptic

Esophageal Motility Disorders

Esophageal Spasm, Diffuse

Deglutition Disorders

Esophageal Diseases

Gastrointestinal Diseases

Precancerous Conditions

Gastroenteritis

Peptic Ulcer

Ulcer

Duodenal Diseases

Intestinal Diseases

Stomach Diseases

Gastrointestinal Agents

All Drugs and Chemicals

Lansoprazole

Dexlansoprazole

Antacids

Anti-Ulcer Agents

Proton Pump Inhibitors

Enzyme Inhibitors

(standard dose-long term): Lansoprazole oral tablets 30 mg once daily (before breakfast on an empty stomach) for 6 months

(standard dose-short term): Lansoprazole oral tablets 30 mg once daily (before breakfast on an empty stomach) for 3 months

Lansoprazole oral tablets 30 mg

The trial would to try to establish:

* The best post-operative PPI prescription protocol after Sleeve Gastrectomy
* The impact of PPI therapy on postoperative peptic diseases (erosive gastropathies, ulcers, duodenitis, esophagitis and/or Barrett)
* The impact of PPI therapy on post-operative GERD symptoms (assessed with the use of two standard tests: MRGE-HRQL and GERDQ

45 patients candidate to primary SG and randomized in 3 study groups (15 per group) GROUP A: no treatment (control group)

GROUP B (standard dose-long term): Lansoprazole buccal tablets 30 mg once daily (before breakfast on an empty stomach) for 6 months

GROUP C (standard dose-short term): Lansoprazole buccal tablets 30 mg once daily (before breakfast on an empty stomach) for 3 months

PPI Therapy Impact on GERD After Sleeve Gastrectomy

Impact of Treatment With Protonic Pump Inhibitors After Laparoscopic Sleeve Gastrectomy on Gastro-esophageal Reflux Disease Symptoms: Pilot Study

Questionnaire evaluation (GERD-HRQL score from 0 (no symptoms) to 5 (symptoms worsening daily activity) and GERD-Q (score A \<8 no GERD, score A \>8 and B \> 3 GERD worsening normal life)

Mucosal damage evaluation and stratified accordingly

University of Roma La Sapienza

MD PhD

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
PPI Therapy Impact on GERD After Sleeve Gastrectomy	NCT04400136	Gastro Esophage... Barrett Esophag... Bariatric Surge...	Lansoprazole or...	18 Years - 65 Years	University of Roma La Sapienza
PPI Therapy Impact on GERD After Sleeve Gastrectomy	NCT04400136	Gastro Esophage... Barrett Esophag... Bariatric Surge...	Lansoprazole or...	18 Years - 65 Years	University of Roma La Sapienza

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