Neoplasms

Symptoms and General Pathology

All Conditions

Wounds and Injuries

Rare Diseases

Neoplasm Metastasis

Rupture

Hyperthermia

Fever

Krukenberg Tumor

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Carcinoma, Signet Ring Cell

Adenocarcinoma

Neoplasms, Cystic, Mucinous, and Serous

Krukenberg Carcinoma

laparotomy plus HIPEC

Diane GOERE, MD

Multicentric randomised trial. Patients with a high risk of developing colorectal Peritoneal Carcinomatosis (PC) after resection of their primary will be informed, will sign the consent and will be pre-registered. All patients will receive the current standard adjuvant treatment : 6 months of systemic chemotherapy (currently the Folfox-4 regimen which could be modified if the standard is modified). Then a work-up is done to exclude recurrence. The likelihood of a recurrence is low but if this occurs, the patient will not be randomised and will be treated with the best known treatment. If the work-up is negative, patients will be randomised to surveillance alone (control group) or exploratory laparotomy + HIPEC (experimental group).

Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients

Multicentric Phase III Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" HIPEC (Hyperthermic Intraperitoneal Chemotherapy) in Colorectal Patients Initially Treated With Surgery and Adjuvant Chemotherapy Who Have a High Risk of Developing Colorectal Peritoneal Carcinomatosis

Gustave Roussy, Cancer Campus, Grand Paris

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients	NCT01226394	Colorectal Canc... Ovarian Metasta... Tumour Rupture ...	laparotomy plus...	18 Years - 70 Years	Gustave Roussy, Cancer Campus, Grand Paris
Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients	NCT01226394	Colorectal Canc... Ovarian Metasta... Tumour Rupture ...	laparotomy plus...	18 Years - 70 Years	Gustave Roussy, Cancer Campus, Grand Paris

Spots Global Cancer Trial Database for laparotomy plus hipec