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Patients who voluntarily accept a regular diet and do not eat again 1h before bedtime

Patients who voluntarily accepted to have an additional meal 1h before bedtime (total calories 200-275kcal, protein 11.5g-18g, complex carbohydrates 25-55g).

have an additional meal 1h before bedtime (total calories 200-275kcal, protein 11.5g-18g, complex carbohydrates 25-55g).

late-evening snacks

Yao Du, Master

Late-evening snacks, in which a portion of food is moved to bedtime while the total amount of food eaten per day remains unchanged, can effectively improve the metabolic state of accelerated catabolism.

The goal of this clinical trial is to learn about the effects of late-evening snacks on health conditions of hepatocellular carcinoma patients who underwent hepatectomy, and to further explore the effects of late-evening snacks on patients' metabolic patterns. The main question it aims to answer are: • the effect of late-evening snacks on the nutritional status of hepatic resection patients with hepatocellular carcinoma;

* the effect of late-evening snacks on the recovery of liver function in liver cancer hepatectomy patients;
* the effect of late-evening snacks on the complication rate of hepatic resection patients with hepatocellular carcinoma;
* the effect of late-evening snacks on long-term quality of life of hepatic resection patients with hepatocellular carcinoma;
* the effect of late-evening snacks on the metabolic pattern of hepatic resection patients with hepatocellular carcinoma.

After learning about the 2 dietary modalities of the late-evening snacks and regular diet, patients will be placed in the different groups according to your preference. Patients who enter the test group will have additional meal 1h before bedtime every day, while patients in the control group will have normal diet. Patients will be asked to :

* eat 1h before bedtime;
* follow the doctor's instructions during their stay in the hospital;
* have follow-up examinations at 1 month, 3 months and 6 months after the operation, after which blood samples will be collected for metabolite testing.

This study utilizes a grouping method based on patient preference. You will learn about the 2 dietary modalities, the late-evening snacks and the regular diet, and then you will be placed in the different groups according to your preference. Patients who volunteer for the 1h bedtime meal will be in the test group and those who volunteer for the regular diet will be in the control group. Dietary counseling and follow-up visits will be conducted in both groups, the difference being the presence or absence of the 1h bedtime meal pattern.

The Effect of Late-evening Snacks on Patients With Primary Hepatocellular Carcinoma After Hepatectomy

Effects of Late-evening Snacks on Nutritional Status and Metabolic Pattern of Patients With Primary Hepatocellular Carcinoma After Hepatectomy

Serum albumin levels in patients at each time point

Serum levels of prealbumin in patients at each time point

Serum levels of alanine aminotransferase in patients at each time point

Serum levels of aspartate aminotransferase in patients at each time point

Serum levels of cholinesterase in patients at each time point

Serum levels of total bilirubin in patients at each time point

Total cost from patient hospitalization to discharge

Time from when the patient achieved complete remission after hepatectomy to the time of recurrence or cutoff for follow-up

Patients completed EORTC QLQ-C30 at various time points

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effect of Late-evening Snacks on Patients With Primary Hepatocellular Carcinoma After Hepatectomy	NCT06278701	Liver Neoplasms	late-evening sn...	18 Years - 75 Years	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
The Effect of Late-evening Snacks on Patients With Primary Hepatocellular Carcinoma After Hepatectomy	NCT06278701	Liver Neoplasms	late-evening sn...	18 Years - 75 Years	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
The Effect of Late-evening Snacks on Patients With Primary Hepatocellular Carcinoma After Hepatectomy	NCT06278701	Liver Neoplasms	late-evening sn...	18 Years - 75 Years	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

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