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35 mg/m2/dose of TAS-102 orally, twice daily on days 1-5 and days 8-12 of each 28-day cycle. Number of cycles: approximately 4 or until discontinuation criteria is met.

35 mg/m2/dose of TAS-102 orally, twice daily on days 1-5 and days 8-12 of each 28-day cycle. Number of cycles: approximately 4 or until discontinuation criteria is met.

The dose level of severe cohort, if enrolled, will be determined based on the Interim Assessment of mild and moderate cohorts.

TAS-102

Study to evaluate the safety, tolerability, and pharmacokinetics of TAS-102 in patients with advanced solid tumors and varying degrees of hepatic impairment.

This is a Phase 1, open-label study to evaluate the safety, tolerability, and pharmacokinetics of TAS-102 in patients with advanced solid tumors with varying degrees of hepatic impairment. The study is conducted in 2 parts: the Pharmacokinetic Part (Cycle 1) and the Extension Part (Cycles 2 and beyond). Patients may continue to receive treatment with TAS-102 during the study extension part only after completion of the Pharmacokinetic Part.

A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Hepatic Impairment

A Phase 1, Open-label Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TAS-102 in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Impairment.

FTD, FTY and TPI: pharmacokinetic parameters Cmax, Tmax, AUC0-last, AUC0-inf, and T1/2. FTD and TPI: CL/F, Vd/F of TAS-102

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Hepatic Impairment	NCT02301104	Advanced Solid ...	TAS-102	18 Years -	Taiho Oncology, Inc.
A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Hepatic Impairment	NCT02301104	Advanced Solid ...	TAS-102	18 Years -	Taiho Oncology, Inc.

Spots Global Cancer Trial Database for lft

Every month we try and update this database with for lft cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for lft

Every month we try and update this database with for lft cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for lft cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.