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Oncological patients: lymphomas (Hodgkin's, DLBCL), breast and ovarian cancers, brain gliomas.

The number at most half as large as the patients' group, composed of healthy people at similar age and the same sex as patients.

The FDG PET/CT imaging will be performed as part of typical medical procedures related to the diagnosis and monitoring of cancers at the Oncology Center in Bydgoszcz, Poland

Patients

Paweł Sutkowy, PhD

The research aims to determine the parameters of oxidative stress and inflammatory processes and compare these parameters with the image obtained using positron emission tomography (PET) with 2-deoxy-2-\[fluorine-18\]fluoro- D-glucose (18F-FDG) integrated with computed tomography (CT) in the group of oncological patients.

FDG PET/CT is very sensitive imaging tool for the detection of neoplasms. Neoplasm tissue is characterized by a much higher level of metabolism than healthy tissues, therefore a 95% cases of use the method regard oncology. Fluorodeoxyglucose (FDG) is absorbed by patients' organism as glucose but it does not undergo metabolism. The increased degree of FDG accumulation in tissue means its higher metabolic activity. FDG accumulates in the tumor tissue and radiates enabling its detection but the substance has not been shown to be harmful to patient at doses used in the diagnostics.

Tumor formation is a multi-stage process in which the phases of initiation, promotion and progression are distinguished. Neoplastic transformation of healthy cells is associated with disturbances of the cell cycle caused by mutations of proto-oncogenes (activation of cell division) and/or suppressor genes (blocking cell division) and mutator genes (protecting the DNA against damage or its repairing) under the influence of various factors. Increasing data indicate that one of the most important factors initiating neoplasm are reactive oxygen species (ROS) and oxidative stress. Mechanisms responsible for induction of oxidative stress in cancer cells are not fully explained. It is known that they are closely related to inflammation, as well as intense cellular metabolism associated with continuous proliferation, mutations in the genetic material and dysfunctions in the mitochondrial respiratory chain.

In this study a number of markers of oxidative stress and inflammation are planned to be determined including: the activities of antioxidant and lysosomal enzymes, as well as concentrations of lipid peroxidation products and low molecular weight antioxidants. The PET/CT imaging will be performed as part of standard medical procedures related to the diagnosis and monitoring of cancer diseases at the Oncology Center in Bydgoszcz, Poland.

Venous blood collected from the basilic vein from the study participants into two vacuum test tubes only once (from patients during FDG PET-CT diagnosis): for full blood (K2EDTA) and blood serum (clot activator and gel separator).

Oxidoreductive Balance and Lysosomal Activity in Cancer Patients.

Oxidative Stress and Inflammatory Processes in Selected Neoplasms in the Group of Oncological Patients Examined With the FDG PET/CT Method.

There is no the individual participant data (IPD) sharing plan.

Total antioxidant potential of blood serum in the participant

Positron emission tomography with 2-deoxy-2-\[fluorine-18\]fluoro- D-glucose integrated with computed tomography

Nicolaus Copernicus University

Assistant professor

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Colorectal Neoplasms

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Group of patients operated with open approach for colorectal cancer

Group of patients operated with laparoscopic approach for colorectal cancer

Open colectomy. Epidural anaesthesia used

Open colectomy

Laparoscopic colectomy. Epidural anaesthesia used

laparoscopic colectomy

Contribution to the study of oxidative stress markers in laparoscopic vs open colectomy for colorectal cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Oxidoreductive Balance and Lysosomal Activity in Cancer Patients.	NCT03470857	Neoplasms Antioxidants Oxidative Stres... Lipid Peroxidat... Inflammation Lysosome Altera...	Patients	18 Years -	Nicolaus Copernicus University
Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer	NCT00928928	Colorectal Canc...	Open colectomy laparoscopic co...	-	G. Hatzikosta General Hospital

Spots Global Cancer Trial Database for lipid peroxidation