Neoplasms

All Conditions

Symptoms and General Pathology

Digestive System Diseases

Rare Diseases

Carcinoma

Neoplasm Metastasis

Carcinoma, Hepatocellular

Cholangiocarcinoma

Liver Neoplasms

Hyperplasia

Hemangioma

Focal Nodular Hyperplasia

Bile Duct Cancer

Nodular Regenerative Hyperplasia

Hematinics

All Drugs and Chemicals

Liver Extracts

liver resection using a bipolar dissector (Erbe), ultracision harmonic scalpel (Ethicon) and water-jet dissector (ERBEJET 2).

liver resection using a bipolar dissector (Erbe), ultracision harmonic scalpel (Ethicon), and ultrasonic aspirator (Misonix/SonaStar Ultrasonic Surgical Aspiration System)

liver transection during laparoscopic liver resection

Mikhail Efanov, MD, PhD

Background: until now, there is no agreement about the safest and feasible method for liver parenchyma transection during laparoscopic liver resection.

Study design: prospective, randomized, single-center The purpose of the study: comparison of short-term results of two methods of parenchyma liver transection during laparoscopic liver resection

two groups will be compared. Group 1: liver resection using a bipolar dissector (Erbe), ultracision harmonic scalpel (Ethicon) and water-jet dissector (ERBEJET 2).

Group 2: liver resection using a bipolar dissector (Erbe), ultracision harmonic scalpel (Ethicon), and ultrasonic aspirator (Misonix/SonaStar Ultrasonic Surgical Aspiration System)

Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection

Morbidity according to Clavien-Dindo classification (it is advisable to activate complications class II-V). The Clavien-Dindo classification (CDC) is a standardized system for the registration of surgical complications. It consists of 7 grades (I, II, IIIa, IIIb, IVa, IVb and V). The major characteristic of the CDC system is that the severity of a complication is graded based on the type of therapy required to treat the complication. The CDC system has been validated and accepted worldwide for use in many fields of surgery. The complications that change the treatment of grade II-V.

Absolute blood loss (ml) will be calculated as the amount of blood (collected only during the parenchyma resection) in suction the container after the subtraction of all irrigating fluids and weighing operative sponges.

Аbsolute measurement of blood loss in relation to resection size (ml/cm\^2).

Duration of liver parenchyma transaction (min)

the number of participants who needed to apply the Pringle maneuver

The total duration of Pringle maneuver (min)

Moscow Clinical Scientific Center

Clinial Research

The definition of adverse event, used to collect adverse event information, no differs from the clinicaltrials.gov Definitions

liver resection using a bipolar dissector (Erbe), ultracision harmonic scalpel (Ethicon) and water-jet dissector (ERBEJET 2).

liver transection during laparoscopic liver resection: liver transection during laparoscopic liver resection

ErbeJet

liver resection using a bipolar dissector (Erbe), ultracision harmonic scalpel (Ethicon), and ultrasonic aspirator (Misonix/SonaStar Ultrasonic Surgical Aspiration System)

liver transection during laparoscopic liver resection: liver transection during laparoscopic liver resection

Misonix

Total

Age, Continuous

Sex: Female, Male

Race and Ethnicity were not collected from any participant.

Race and Ethnicity Not Collected

Body mass index (BMI)

ASA 1

ASA 2

ASA 3

ASA 1: A normal healthy patient. ASA 2: A patient with a mild systemic disease. ASA 3: A patient with a severe systemic disease that is not life-threatening. ASA 4: A patient with a severe systemic disease that is a constant threat to life. ASA 5: A moribund patient who is not expected to survive without the operation. The patient is not expected to survive beyond the next 24 hours without surgery. ASA 6: A brain-dead patient whose organs are being removed with the intention of transplanting them into another patient.

Physical status classification system (ASA)

Malignant

Bening

Malignant/benign lesions

Tumor size (mm)

Postero-superior segments

IWATE criteria proposed at the International Consensus Conference on Laparoscopic Liver Resection as difficulty scoring system for laparoscopic liver resection. Difficulty index includes the type of liver resection (partial resection, segmentectomy, and sectionectomy), the size and topography of the tumor, its proximity to the large vessels of the liver, the presence and stage of liver cirrhosis (CTP) and has a scale ranging from 0 to 12. Difficalty level: low 0-4, intermediate 4-6, advanced 7-9, expert 10-12.

Difficulty index score (IWATE Criteria) Low\Intermediate\Advanced\Expert

an addition to the exclusion criteria specified in the design of the study, the latter were expanded due to the following position. This made it difficult to recruit patients to the study.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection	NCT03208192	Liver Transecti...	liver transecti...	18 Years - 80 Years	Moscow Clinical Scientific Center
Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection	NCT03208192	Liver Transecti...	liver transecti...	18 Years - 80 Years	Moscow Clinical Scientific Center

Spots Global Cancer Trial Database for liver transection during laparoscopic liver resection