Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Rare Diseases

Uterine Cervical Dysplasia

Precancerous Conditions

Uterine Cervical Diseases

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Cervical Intraepithelial Neoplasia

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

The LLETZ procedure will be performed under local anaesthesia

The LLETZ procedure will be performed under general anaesthesia

Conization will be performed under local anaesthesia

LLETZ under local anaesthesia

Conization will be performed under general anaesthesia

LLETZ under general anaesthesia

Ziad Hilal, M.D.

The investigators conduct a prospective, randomized trial to assess the benefits of performing large loop excision of the transformatione zone (LLETZ) under local anesthesia and compare it to LLETZ under general anesthesia. The primary endpoint of this study is women´s satisfaction.

LLETZ Under General Versus Local Anesthesia

Large Loop Excision of the Transformatione Zone Under General Versus Local Anesthesia: a Randomized Trial.

Patients will score their satisfaction by using a 11-step visual analogue scale (VAS) ranging from '0' ("not satisfied at all") to '10' ("very satisfied") 2 hours after Treatment

patients will score their postoperative pain Level using a 11-step visual analogue scale (VAS) ranging from '0' ("no pain" ) to '10' ("maximum pain") within 2 hours after surgery

the resected cone mass will be quantified by weighing the removed tissue with a precision scale located in the operating room

the time from the beginning of the Operation (start of the electrosurgical method) until the end of the operation (the end of hemostatic interventions) will be measured in minutes

Operative complications defined as necessity to intervene therapeutically up to 14 days postoperatively

the time until complete hemostasis as judged by the surgeon has been achieved, will be measured in seconds

Surgeons will score their satisfaction by using a 11-step visual analogue scale (VAS) 20 minutes after Treatment

surgeons will count the number of the surgical specimen (1 vs. \>1)

The circumference, length and thickness of The surgical specimens will be measured

intraoperative blood loss will be measured using the difference in serum hemoglobin one day prior to surgery and within 5 hours postoperatively

Resection margin is judge as "R0" if abnormal cells are not found in the margin of the biopsy or "R1" if abnormal cells remain in the margin of the biopsy. The histopathological examination will be done by an Independent pathologist

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
LLETZ Under General Versus Local Anesthesia	NCT03494686	Uterine Cervica...	LLETZ under loc... LLETZ under gen...	18 Years -	Zydolab - Institute of Cytology and Immune Cytochemistry
LLETZ Under General Versus Local Anesthesia	NCT03494686	Uterine Cervica...	LLETZ under loc... LLETZ under gen...	18 Years -	Zydolab - Institute of Cytology and Immune Cytochemistry

Spots Global Cancer Trial Database for lletz under local anaesthesia