Neoplasms

All Conditions

Symptoms and General Pathology

Blood and Lymph Conditions

Rare Diseases

Carcinoma

Carcinoma, Transitional Cell

Hypertrophy

Lymphadenopathy

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Transitional Cell Carcinoma

Template-based LND was carried out in all patients in this group. The anatomical extent of LND is described in previous study. Lymph node specimens were sampled "en bloc" with surrounding adipose tissue, and were sent to pathological examination as individual packets with the surrounding adipose tissue.

LND was carried out only in patients who have lymph nodes enlargement in preoperative imaging (CTU or enhanced MRI) or who were found lymph nodes enlargement during surgery.

Routine Template-based lymphadenectomy

LND was carried out only in patients who have lymph nodes enlargement in preoperative imaging (e.g. CTU or enhanced MRI) or who were found lymph nodes enlargement during surgery

LND only for lymph nodes enlargement found in preoperative image or during surgery

jiwei huang, M.D.

Xuesong Li, M.D

Jiwei Huang, M.D

Wei Xue, M.D

Liqun Zhou, M.D

Recent studies showed the therapeutic benefit of lymphadenectomy in advanced stage urothelial carcinoma of the upper urinary tract, but there is still a lack of prospective studies. Thus, the current guideline recommends lymph node dissection for invasive upper tract urothelial carcinoma (UTUC) on the basis of insufficient evidence. Also, the preoperative judgment of muscle invasive pathological stage T 2+,or N+ is difficult from preoperative imaging. In the investigators' clinical practice, the surgeons performed dissection of regional lymph nodes only in patients with enlargement of lymph nodes found in preoperative imaging or during surgery. The aim of this multi-institutional study was to examine the role of lymphadenectomy in urothelial carcinoma of the upper urinary tract.

Prognostic Value of Lymph Node Dissection in Patients With Transitional Cell Carcinoma of the Upper Urinary Tract

Prospective Randomized Phase II Trial: Comparing the Prognostic Value of Routine Lymphadenectomy Versus Lymphadenectomy Only for Lymph Nodes Enlargement Found in Preoperative Imaging or During Surgery Undergoing Nephroureterectomy in Patients With Primary Upper Tract Urothelial Carcinoma

Disease free survival rate in the 36 month following nephroureterectomy

Cancer specific survival rate in the 36 month following nephroureterectomy

Overall survival rate in the 36 month following nephroureterectomy

The recurrence rate of bladder cancer in the 36 month following nephroureterectomy

Perioperative complications were evaluated up to 90 days after surgery, and were graded by Clavien-Dindo classiﬁcation

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Prognostic Value of Lymph Node Dissection in Patients With Transitional Cell Carcinoma of the Upper Urinary Tract	NCT03474926	Lymph Node Diss...	Routine Templat... LND only for ly...	15 Years - 80 Years	RenJi Hospital
Prognostic Value of Lymph Node Dissection in Patients With Transitional Cell Carcinoma of the Upper Urinary Tract	NCT03474926	Lymph Node Diss...	Routine Templat... LND only for ly...	15 Years - 80 Years	RenJi Hospital

Spots Global Cancer Trial Database for lnd only for lymph nodes enlargement found in preoperative image or during surgery