Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Recurrence

Prostatic Neoplasms

Disease Attributes

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Patients with recurrent prostate cancer undergoing SCAP

Patients with recurrent prostate cancer undergoing HIFU

Once the local involvement of the recurrent prostate cancer is confirmed, patient will undergo local treatment of the prostate (SCAP or HIFU)

Local treatment of the prostate (SCAP or HIFU)

Ignacio Puche Sanz, MD PhD

Guillaume Ploussard, MD PhD

Enrique Gómez-Gómez

Ignacio Puche-Sanz

Ignacio Osman

Ignacio Puche-Sanz, MD, PhD

Enrique Gomez-Gomez, MD

The evidence base relating to the use of SCAP and HIFU is poor, with significant uncertainties relating to long-term oncological outcomes. One of the main limitations when the few studies reported are analyzed is the lack of information about the histopathology both before starting treatment and at the time of recurrence after cryotherapy. The vast majority of studies refer only to BCR-free survival as end point, thus limiting interpretation of real oncological performance of this technique. Furthermore, side effects vary widely from study to study and there are uncertainties about the real morbidity associated to cryotherapy in the salvage setting.

Another important hot issue in this scenario is the potential benefit that new imaging and diagnosis techniques (MRI, targeted biopsy, PSMA) may add for a more accurate indication. This could provide the possibility of better results for SCAP. The clinical value of this new diagnostic tools is unknown in this scenario and needs to be explored.

SCAP vs HIFU for Recurrent Prostate Cancer After Radiation Therapy

Salvage Cryoablation of the Prostate (SCAP) vs High Intensity Focal Ultrasounds (HIFU) for Recurrent Prostate Cancer After Radiation Therapy

Disease free survival (confirmed by follow-up biopsy)

Disease free survival (confirmed by follow-up PET-CT )

Androgen deprivation therapy free survival.

Time free of biochemical recurrence (PSA)

Metastasis free survival. rate of patients without any metastasis detected on PET-CT.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
SCAP vs HIFU for Recurrent Prostate Cancer After Radiation Therapy	NCT05044754	Cryotherapy High Intensity ... Recurrent Prost...	Local treatment...	18 Years - 90 Years	University Hospital Virgen de las Nieves
SCAP vs HIFU for Recurrent Prostate Cancer After Radiation Therapy	NCT05044754	Cryotherapy High Intensity ... Recurrent Prost...	Local treatment...	18 Years - 90 Years	University Hospital Virgen de las Nieves

Spots Global Cancer Trial Database for local treatment of the prostate (scap or hifu)