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Maytansine

LOP628

Novartis Pharmaceuticals

LOP628 is an antibody-drug conjugate (ADC) consisting of an anti-cKit humanized IgG1/κ antibody conjugated to a maytansine payload via a non-cleavable linker.

LOP628 provides an opportunity to target cKit overexpressing tumors.

Phase 1 Study of LOP628 in Adult Patients With cKit-positive Solid Tumors and Acute Myeloid Leukemia

A Phase I, Multicenter, Open-label Dose Escalation and Expansion Study of LOP628, Administered Intravenously in Adult Patients With cKit-positive Tumors and Acute Myeloid Leukemia

To estimate the maximum tolerated dose/recommended dose for expansion (MTD/RDE)

Characterize the safety and tolerability of LOP628

To characterize the pharmacokinetic profile of LOP628

To characterize the pharmacokinetic profile of LOP628.

To assess the preliminary anti-tumor activity of LOP628

To assess the preliminary anti-tumor activity of LOP628 in patients

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Phase 1 Study of LOP628 in Adult Patients With cKit-positive Solid Tumors and Acute Myeloid Leukemia	NCT02221505	cKIT-positive S... AML	LOP628	18 Years -	Novartis
Phase 1 Study of LOP628 in Adult Patients With cKit-positive Solid Tumors and Acute Myeloid Leukemia	NCT02221505	cKIT-positive S... AML	LOP628	18 Years -	Novartis

Spots Global Cancer Trial Database for lop628

Every month we try and update this database with for lop628 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for lop628

Every month we try and update this database with for lop628 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for lop628 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.