Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Lung Neoplasms

Lymphoma

Hodgkin Disease

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Lymphosarcoma

Hodgkin Lymphoma

All participants are invited to undergo a low dose CT thorax

A low dose CT scan of the thorax to screen for lung cancer

Low dose CT thorax

A single site non-commercial study in which people treated for Hodgkin lymphoma survivors will be invited to have a single low dose CT of thorax for lung cancer screening

Lung Screening in People Cured of Hodgkin Lymphoma

Lung Screening for Hodgkin Lymphoma Survivors: a Feasibility Study

University of Manchester

The Christie NHS Foundation Trust

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Age 50-75, men or women, smokers or non-smokers. Being first degree relatives (siblings, children and parents) of lung cancer subjects. Having no known lung cancer before.

Non-lung cancer subjects who are not related any lung cancer patients

A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.

Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects

David CL Lam, MBBS, FRCP(Edin), FCCP, FACP

Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.

The primary aim of this prospective study is to find out the rate of lung cancer detection in subjects who are first degree relatives of lung cancer patients. Secondary aims include studying the characteristics of screen-detected lung cancer. This is a multi-centered prospective cohort study. 1,520 subjects who are first degree relatives of lung cancer patients at four public hospitals in Hong Kong will be screened. Intervention Detailed questionnaires and LDCT Thorax will be performed. The primary outcome measure is the number of lung cancers detected by this study. The screening-detection rate of lung cancer in first-degree relatives of lung cancer patients will be estimated.

Screening for Lung Cancer in Subjects With Family History of Lung Cancer

The relevant biomarkers from blood and urine sample collected

The number of screening-detected lung cancer among first degree relatives of lung cancer patients.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Lung Screening in People Cured of Hodgkin Lymphoma	NCT04986189	Hodgkin Lymphom... Lung Cancer	Low dose CT tho...	18 Years - 80 Years	The Christie NHS Foundation Trust
Lung Screening in People Cured of Hodgkin Lymphoma	NCT04986189	Hodgkin Lymphom... Lung Cancer	Low dose CT tho...	18 Years - 80 Years	The Christie NHS Foundation Trust
Screening for Lung Cancer in Subjects With Family History of Lung Cancer	NCT05762731	Lung Cancer	Low dose CT tho... Low dose CT tho...	50 Years - 75 Years	The University of Hong Kong

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