Blood and Lymph Conditions

All Conditions

Neoplasms

Heart and Blood Diseases

Rare Diseases

Myeloproliferative Disorders

Polycythemia Vera

Polycythemia

Primary Myelofibrosis

Thrombocytosis

Thrombocythemia, Essential

Bone Marrow Diseases

Hematologic Diseases

Bone Marrow Neoplasms

Hematologic Neoplasms

Blood Platelet Disorders

Hemostatic Disorders

Blood Coagulation Disorders

Hemorrhagic Disorders

Chronic Myeloproliferative Disorders

Essential Thrombocythemia

LY2784544 will be taken by mouth per a specified schedule. Different participants will be treated at different doses until reaching the highest dose a participant can tolerate. Each cycle is 28 days.

LY2784544 will be taken by mouth per a specified schedule. Different participants will be treated at different doses from Part A that are determined to be safe and have potential clinical merit. Each cycle is 28 days.

LY2784544 will be taken by mouth per a specified schedule. Each cycle is 28 days.

LY2784544

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

The purpose of this study is to determine a dose of LY2784544 that may be safely administered to participants with myeloproliferative neoplasms.

Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms

A Phase 1 Study of LY2784544 Testing Alternative Dosing Regimens in Patients With Myeloproliferative Neoplasms

Eli Lilly and Company

LY2784544 will be supplied as a capsule. The study drug will be taken by mouth daily while the patient is on study. In this study, different patients will be treated at different doses of LY2784544 until reaching the highest dose that patients can tolerate.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

The purpose of this study is to find out the safe dose range of the study drug in patients with myeloproliferative disorders.

The purpose of the study is to learn:

1. How much and how often LY2784544 should be given to patients
2. What is the safety profile of LY2784544 and any side effects that might be associated with it
3. How LY2784544 is taken up, distributed, broken down, and passed out of your body
4. Whether LY2784544 can help patients with myeloproliferative disorders
5. If any markers in the blood (biomarkers) can identify patients who will respond better to the study drug.

The planned duration of the study is not fixed. The length of time patients participate in the study will be determined by the investigator/study doctor.

Part A of the study is to determine the dose of the study drug. Part A is divided into two sections, A1 and A2. In Part A1, patients will be given study drug without a lead-in period. In Parts A2 and B, patients will have a lead-in period of 2 or 4 weeks with a low dose of LY2784544 prior to taking a higher dose of LY2784544. Part B of the study is to confirm the safety of the dose and schedule.

A Study in Myeloproliferative Disorders

A Phase 1 Study of LY2784544 in Patients With JAK2 V617F-Positive Myeloproliferative Disorders

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms	NCT01520220	Myeloproliferat... Polycythemia Ve... Essential Throm... Myelofibrosis	LY2784544	18 Years -	Eli Lilly and Company
A Study in Myeloproliferative Disorders	NCT01134120	Myeloproliferat... Thrombocythemia... Polycythemia Ve... Primary Myelofi...	LY2784544	18 Years -	Eli Lilly and Company

Spots Global Cancer Trial Database for ly2784544

Every month we try and update this database with for ly2784544 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for ly2784544

Every month we try and update this database with for ly2784544 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for ly2784544 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.