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Photodynamic therapy using Photosan and LumaCare™ Lamp Model LC-122M

Jui-Chang Tsai, M.D. Ph.D.

Primary Objective:

* The primary objective is to evaluate the efficacy of photodynamic therapy in the treatment of malignant intracranial tumors.

Secondary Objective:

* The secondary objective is to evaluate the safety of photodynamic therapy in the treatment of malignant intracranial tumors.

After passing Photosan® allergic test, the patients will be injected intravenously with Photosan® (2mg/kg) during 15\~30 minutes, 48 hours prior to a standard craniotomy. Precautions are taken not to expose the patient in the operating room to direct room or operating light and to shield the skin of the flap during operation. Steroids are withdrawn 2-3 days prior to sensitization. After maximal resection, the surface of the tumor bed will be calculated and the generated cavity kept with a balloon containing intralipid (0.1%) or saline and/or artificial spinal fluid in it. A fiber with a spherical diffuser will be centered in the cavity and the surface irradiated with red (625\~635nm) Halogen light. The dose of light irradiation depends on individual condition of the patient, usually with an energy density of 100 J/cm2 at a power density of 500 mW/cm2 to 600 mW/cm2.

Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors

Prospective, Open-labeled, Clinical Trial in Compassionate Use to Evaluate the Efficacy and Safety of Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors

National Taiwan University Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors	NCT00243490	Malignant Intra... Glioblastoma Mu... Anaplastic Astr... Anaplastic Olig... Anaplastic Epen...	Photodynamic th...	20 Years - 75 Years	National Taiwan University Hospital
Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors	NCT00243490	Malignant Intra... Glioblastoma Mu... Anaplastic Astr... Anaplastic Olig... Anaplastic Epen...	Photodynamic th...	20 Years - 75 Years	National Taiwan University Hospital

Spots Global Cancer Trial Database for malignant intracranial tumors