Neoplasms

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Nasopharyngeal Carcinoma

Neoplasms, Glandular and Epithelial

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Nasopharyngeal Neoplasms

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Locoregionally advanced nasopharyngeal carcinoma patients received concurrent chemoradiotherapy

Locoregionally advanced nasopharyngeal carcinoma patients received induction chemotherapy and concurrent chemoradiotherapy

Locoregionally advanced nasopharyngeal carcinoma patients received platinum-based/non-platinum based concurrent chemoradiotherapy.

CCRT

Locoregionally advanced nasopharyngeal carcinoma patients received induction chemotherapy and platinum-based/non-platinum based concurrent chemoradiotherapy.

IC+CCRT

Xiang Guo, MD, PhD

To investigate whether the additional induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) was able to improve overall survival (OS) and disease-free survival (DFS), and to clarify if stage-specified chemoradiotherapy regimens benefit the most for locoregionally advanced NPC.

Data of patients firstly diagnosed NPC from Jan 1st, 1998 to Jun 1st, 2013 were downloaded from Department of Medical Information, Sun Yat-Sen University Cancer Center. Patients were excluded if they had stage I or II disease, no complete medical records, received treatment previously, or without concurrent chemoradiotherapy. Follow-up data is updated on October 1st, 2015.The propensity score-matching (PSM) method was adopted to balance observed covariates between both groups. Propensity scores reflect the conditional probability that is intended to be uniform between patients received CCRT and IC+CCRT based on their baseline characteristics. Matching was performed based on nearest-neighbor matching, and comparing between CCRT and IC+CCRT patients were matched within their respective risk groups.

Retrospective Investigation of the Impacts of Prognosis for Nasopharyngeal Carcinoma Patients

Stage-specified Concurrent Chemoradiotherapy With or Without Induction Chemotherapy for Locoregionally-advanced Nasopharyngeal Carcinoma - A Retrospective, Population-based Study

Sun Yat-sen University

associate professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Retrospective Investigation of the Impacts of Prognosis for Nasopharyngeal Carcinoma Patients	NCT02604472	Malignant Neopl...	CCRT IC+CCRT	-	Sun Yat-sen University
Retrospective Investigation of the Impacts of Prognosis for Nasopharyngeal Carcinoma Patients	NCT02604472	Malignant Neopl...	CCRT IC+CCRT	-	Sun Yat-sen University

Spots Global Cancer Trial Database for malignant neoplasm of other specified site of nasopharynx