Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Rare Diseases

Breast Neoplasms

Carcinoma

Sarcoma

Skin Neoplasms

Soft Tissue Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Connective and Soft Tissue

Breast Diseases

Skin Diseases

Soft Tissue Sarcoma

Participants undergo PAI on different parts of the body over 20 minutes for up to 5 imaging sessions for 6 months.

Photoacoustic Imaging

Anurag Singh

This pilot trial studies how well photoacoustic imaging works in diagnosing changes in tumors in participants with breast cancer, sarcoma, skin cancer, or soft tissue malignancy and healthy volunteers. Photoacoustic imaging is a low-risk imaging method that provides information about the oxygenation of tissues using a combination of light and ultrasound techniques. Photoacoustic imaging uses a signal from hemoglobin to provide information on blood flow and oxygen levels, and it may be helpful in determining changes in tumors after chemotherapy or radiation treatment.

PRIMARY OBJECTIVES:

I. To define the feasibility of the current photoacoustic imaging (PAI) technology in various groups of human subjects.

SECONDARY OBJECTIVES:

I. To define the utility of the current PAI on various groups of human subjects.

II. When possible, via means of an existing data review, PAI will be correlated with standard imaging modalities performed on patients as routine part of clinical care or on protocol.

III. When possible, via means of an existing data review, PAI will be compared to pathologic specimens.

IV. When possible, via means of an existing data review, PAI data will be correlated with outcomes of patients to therapies they receive.

OUTLINE:

Participants undergo PAI on different parts of the body over 20 minutes for up to 5 imaging sessions for 6 months.

Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers

A Pilot Study of Photoacoustic Imaging (PAI)

This will be deemed a success if at least 3 imaging sessions produce a usable image. Usable datasets will be defined as those images with detectable PAI signal with minimal or no artifacts within the region of interest. This analysis will be done in the imaged sample, consisting of enrolled patients who attempt at least one imaging session. Patients who do not attempt at least one imaging session will be replaced.

This will be explored by comparison with disease and outcome characteristics collected during routine cancer treatment, including standard imaging modalities, pathology results, and clinical outcomes. Results of these analyses are intended to inform development of early stage (Phase 1/2) clinical trials that consider PAI summaries as biomarkers for treatment response.

This will be correlated with disease and patient characteristics using Analysis of Variance (ANOVA ) for categorical factors

This will be correlated with disease and patient characteristics using OLS regression for continuous factors

This will be correlated with disease and patient characteristics using Cox Regression models for progression and overall survival.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers	NCT03630601	Breast Carcinom... Healthy Subject Malignant Soft ... Sarcoma Skin Carcinoma	Photoacoustic I...	18 Years -	Roswell Park Cancer Institute
Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers	NCT03630601	Breast Carcinom... Healthy Subject Malignant Soft ... Sarcoma Skin Carcinoma	Photoacoustic I...	18 Years -	Roswell Park Cancer Institute

Spots Global Cancer Trial Database for malignant soft tissue neoplasm