Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

Patients will undergo yearly two-view (Mx) and breast US

Magnetic Resonance Imaging (MRI)

Mammography (Mx) + ultrasonography (US)

Paolo Bruzzi, MD

Antonella Petrillo, MD

Paolo Belli, MD

Alessandro Del Maschio, MD

Laura Martincich, MD

Massimo Bazzocchi, MD

Piero Panizza, MD

Stefania Montemezzi, MD

Federica Pediconi, MD

Stefano Corcione, MD

Massimo Calabrese, MD

Francesco Sardanelli, MD

A multicenter randomized controlled trial to evaluate the performance of MRI, in terms of sensitivity, specificity, and predictive value, in the screening of women at intermediate risk of breast cancer.

Two surveillance programs will be compared. Women will be randomly assigned with a 1:1 ratio to:

1. Yearly two-view mammography (Mx) and breast ultrasonography (US) or
2. Yearly MRI.

Women, who, due to an increased risk of invasive breast cancer, are offered a specific surveillance program, as a supplement to the standard screening activities which in Italy are based on mammography every two years starting at age 50.Women will be randomly assigned to Yearly two-view mammography (Mx) and breast ultrasonography (US) or to Yearly MRI.

Contrast-enhanced MR Imaging as a Breast Cancer Screening in Women at Intermediate Risk

A Multicenter Randomised Trial of Contrast-enhanced MR Imaging as a Breast Cancer Screening Tool Alternative to Mammography and Ultrasonography in Women at Intermediate Risk. Feasibility, and Short Term Results.

The performance of MRI will be evaluated , in terms of sensitivity, specificity, and predictive value, in the screening of women at intermediate risk of breast cancer

Prof. Paolo Bruzzi

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Contrast-enhanced MR Imaging as a Breast Cancer Screening in Women at Intermediate Risk	NCT02210546	Breast Cancer	Magnetic Resona... Mammography (Mx...	40 Years - 59 Years	IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Contrast-enhanced MR Imaging as a Breast Cancer Screening in Women at Intermediate Risk	NCT02210546	Breast Cancer	Magnetic Resona... Mammography (Mx...	40 Years - 59 Years	IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Contrast-enhanced MR Imaging as a Breast Cancer Screening in Women at Intermediate Risk	NCT02210546	Breast Cancer	Magnetic Resona... Mammography (Mx...	40 Years - 59 Years	IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

Spots Global Cancer Trial Database for mammography (mx) + ultrasonography (us)