Heart and Blood Diseases

All Conditions

Neoplasms

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Coronary Artery Disease

Lymphoma

Coronary Disease

Myocardial Ischemia

Hodgkin Disease

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Lymphosarcoma

Hodgkin Lymphoma

Not relevant (there is no intervention in the present study)

Yafim Brodov, MD

Mediastinal irradiation for treatment of malignancy increases the risk for coronary artery disease (CAD), while diabetes mellitus or other known risk factors can be absent at the time of the first coronary event. Radiation-induced atherosclerosis affects the coronary ostia and proximal coronary segments, or causes diffuse microvascular damage. Younger patients and those exposed to high radiation doses (\> 35 Gy) have a higher risk for developing premature CAD and likely may benefit from coronary assessment.

A novel hybrid imaging technique that combines SPECT and CTCA has been shown to overcome the individual pitfalls and the diagnostic challenges of stand-alone SPECT and CCTA, improve the lesion detectability and sensitivity in patients with balanced diffuse lesions as well as the specificity and mainly PPV of CTCA.

The aim of the study is to perform hybrid SPECT/CTCA in asymptomatic patients with HL who have received radiotherapy to the mediastinum in order to allow an early diagnosis of hemodynamically significant CAD that will need further therapeutic interventions.

Hybrid SPECT/CTCA for the Assessment of the Presence and Hemodynamic Significance of CAD in Asymptomatic Patients.

Hybrid Single-Photon Emission Computed Tomography/Computed Tomography Coronary Angiography for the Assessment of the Presence and Hemodynamic Significance of CAD in Asymptomatic Patients After Mediastinal Irradiation for Hodgkin Lymphoma.

Rambam Health Care Campus

Antineoplastic Agents

All Drugs and Chemicals

Bleomycin

Carbon Monoxide

Tests include; total lung capacity, vital capacity, functional residual capacity, forced vital capacity, forced expiratory volume in 1 second, carbon monoxide diffusing capacity, pulse oximetry before and after a 6 minute walk and Pulmonary Status and Dyspnea Questionnaire

Pulmonary Function Tests

Obtained at different time points during the study depending upon standard of care chemotherapy treatment

CAT Scan

Andrea K. Ng, MD, MPH

The purpose of this study is to find out the impact Bleomycin-containing chemotherapy, given with or without chest radiation therapy, on patients' lung function over time.

* The tests and procedures in this study are part of regular cancer care but this study offers more structured timing of these standard tests.
* Due to the potential lung toxicity associated with bleomycin-based chemotherapy, pulmonary function tests are routinely performed. Pulmonary function tests will be performed by a licensed, registered respiratory therapist and performed prior to the beginning of treatment, between the chemotherapy and radiation therapy (only for patients receiving both chemotherapy and radiation therapy), and at approximately 1 month, 6 months, 1 year and 2 years after the completion of all treatments.
* A CAT scan will be performed prior to the beginning of treatment, and approximately 1 month, 6 months, 1 year and 2 years after the completion of all treatments.
* A self-administered questionnaire will be performed on the days the patient is undergoing pulmonary function tests.

Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy

A Prospective Study of Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy With or Without Mediastinal Irradiation

Brigham and Women's Hospital

Dana-Farber Cancer Institute

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Hybrid SPECT/CTCA for the Assessment of the Presence and Hemodynamic Significance of CAD in Asymptomatic Patients.	NCT01239446	Hodgkin Lymphom...	Not relevant (t...	18 Years - 65 Years	Rambam Health Care Campus
Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy	NCT00165438	Hodgkin's Disea...	Pulmonary Funct... CAT Scan	18 Years -	Dana-Farber Cancer Institute
Hybrid SPECT/CTCA for the Assessment of the Presence and Hemodynamic Significance of CAD in Asymptomatic Patients.	NCT01239446	Hodgkin Lymphom...	Not relevant (t...	18 Years - 65 Years	Rambam Health Care Campus
Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy	NCT00165438	Hodgkin's Disea...	Pulmonary Funct... CAT Scan	18 Years -	Dana-Farber Cancer Institute
Hybrid SPECT/CTCA for the Assessment of the Presence and Hemodynamic Significance of CAD in Asymptomatic Patients.	NCT01239446	Hodgkin Lymphom...	Not relevant (t...	18 Years - 65 Years	Rambam Health Care Campus
Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy	NCT00165438	Hodgkin's Disea...	Pulmonary Funct... CAT Scan	18 Years -	Dana-Farber Cancer Institute

Spots Global Cancer Trial Database for mediastinal irradiation