Symptoms and General Pathology

All Conditions

Neoplasms

Skin and Connective Tissue Diseases

Diseases and Abnormalities at or Before Birth

Rare Diseases

Syndrome

Carcinoma

Carcinoma, Squamous Cell

Melanoma

Keratosis, Actinic

Keratosis

Lichen Planus

Carcinoma, Basal Cell

Keratosis, Seborrheic

Carcinosarcoma

Mixed Tumor, Mullerian

Lentigo

Dysplastic Nevus Syndrome

Nevus, Pigmented

Hutchinson's Melanotic Freckle

Nevus

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms, Nerve Tissue

Nevi and Melanomas

Skin Neoplasms

Skin Diseases

Neoplasms, Squamous Cell

Precancerous Conditions

Neoplasms, Basal Cell

Lichenoid Eruptions

Exanthema

Skin Diseases, Papulosquamous

Sarcoma

Neoplasms, Connective and Soft Tissue

Melanosis

Hyperpigmentation

Pigmentation Disorders

Neoplastic Syndromes, Hereditary

Genetic Diseases, Inborn

Malignant Mixed Mullerian Tumor

Neuroendocrine Tumor

Neuroepithelioma

Soft Tissue Sarcoma

Anti-Infective Agents

All Drugs and Chemicals

Dermatologic Agents

Chlorhexidine

Chlorhexidine gluconate

Individuals without skin damage (melanoma, BCC, SCC, etc)

Individuals diagnosed with confirmed skin damage by Dermatologists

Two sets of measurements will be performed to each subject, either at a nevus in contrast with a nearby clear patch of skin. The duration of each measurement will last for approximately 1.5 minutes and the excel file will be directly available to researcher, allowing him/her for data storage and data visualization.

Electrical Impedence Spectroscopy DermaSense

Emmanouil Papanastasiou, Dr.

The purpose of this clinical study is to evaluate if the DermaSense prototype EIS scanner can provide medical decision support which can complement dermoscopy-based identification of the disease at time of biopsy decision.

This is a clinical study designed to evaluate if the DermaSense device can be a system of an automated analysis and classification of skin lesions aiming to provide a comprehensive, reliable and cost-effective approach to assist the Dermatologists' decision (biopsy, dermoscopy, histopathological analysis etc). The study enrollment will continue until a minimum of 180 subjects are enrolled in the study. Second Department of Dermatology, School of Medicine, Faculty of Health Sciences of the Aristotle University of Thessaloniki, at the "Papageorgiou" General Hospital will participate in this study. Dermatologists participating in the study will perform the patient and lesion assessment for biopsy as standard of care at the clinic.

EIS (electrical impedance spectroscopy) measurements will be done once per participant recommended by the Dermatologist based on their clinical interest in various areas of the skin. Two sets of measurements will be performed for each participant, either at a nevus in contrast with a nearby clear patch of skin, or at a skin damage area (melanoma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), etc) in contrast with a nearby clear patch of skin. Also, more repeated measurements may be needed to determine the validity of the measurement result. Evaluation and analysis of the measurement data will be done by the DermaSense team and will be used not only for applying appropriate statistical correlations compared to established dermatological diagnostic methods (eg dermοscopy, histopathological examinations, biopsies etc.) but also for training in artificial intelligence and machine learning methods. Finally, the participants will sign a consent form that is consistent with bioethical rules and according with EU GDPR regulation to protect their personal data.

Use of Electrical Impedance Spectroscopy (EIS) for Early Diagnosis of Skin Damage

Comparative Study of Electrical Impedance Spectroscopy (EIS) Models Against Verified Dermatological Diagnostic Data

Use of DermaSense prototype EIS scanner in detecting significant electrical impedance differences between malignant and benign skin lesions.

Use of DermaSense prototype EIS scanner in measuring Electrical Impedance Spectroscopy (EIS) at 10 different frequencies in skin of various body surfaces.

Setting DermaSense prototype EIS scanner in clinical diagnosis of skin lesions, or at least as a potential decision support tool to more accurately identify skin lesions for surgical excision and histopathologic evaluation.

Aristotle University Of Thessaloniki

Assistant Professor

Lawrence E Gibson, MD

The purpose of this study is to estimate and define the mean number, degree of confluence, and depth of penetration of melanocytes in chronically sun exposed skin of the head and neck using Mart-1 immunostains on frozen sections. The study was conducted to confirm whether similar results were found using permanent sections. The present study used hematoxaline and eosin (H\&E) staining as well as Mart-1 staining, and included patients from both Mayo Clinic Jacksonville and Rochester.

For each study participant we recorded their age, sex, state they lived in, tumor type, tumor location, recent sun exposure (during the two weeks prior to the surgery), whether or not a follicle was present on the slide, and if so the follicular extension (mm) from the granular layer, presence of atypia, nesting, pagetoid spread. Two slides were obtained; one stained with Mart-1; the other with H\&E. For both, melanocyte counts per high power field (400 X HPF magnification) were obtained in three locations of the slide. The mean of the 3 counts was used for analysis, though the individual counts were considered in some data summaries (see below). Classification of photo-aging according to the Glogau scale was noted by the surgeon as type1: "no wrinkles"; type II "wrinkles in motion"; type III "wrinkles at rest" and type IV "only wrinkles." Confluence was categorized by the number of adjacent melanocytes as none, mild (2 side-by-side), moderate (3-6), or severe (7 or more).

The proposed dog-ears excised, that were to be discarded during reconstruction, were evaluated for the presence of any visible lesions (i.e. ephelid, lentigo, seborrheic keratosis, nevi). Dog-ears with any skin lesions were excluded. The specimens were inked by the surgeon on the side to be cut by the histotechnician. The specimens were placed in formalin bottles and submitted to the pathology department at Mayo Clinic Rochester for processing. The tissue was cut (4 microns) along its long access and stained with routine H\& E and Mart-1 (MelanA) immunostains.

Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin

Immunohistochemical Analysis of Melanocytes in Sun-Exposed Skin

Mayo Clinic

Lawrence E. Gibson, M.D.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Use of Electrical Impedance Spectroscopy (EIS) for Early Diagnosis of Skin Damage	NCT04688749	Melanoma (Skin) Basal Cell Carc... Squamous Cell C... Dysplastic Nevu... Lentigo Maligna Seborrheic Kera... Lichen Planus-L... Carcinosarcoma	Electrical Impe...	8 Years - 90 Years	Aristotle University Of Thessaloniki
Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin	NCT00875381	Carcinoma, Basa... Carcinoma, Squa...		18 Years -	Mayo Clinic
Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin	NCT00875381	Carcinoma, Basa... Carcinoma, Squa...		18 Years -	Mayo Clinic
Use of Electrical Impedance Spectroscopy (EIS) for Early Diagnosis of Skin Damage	NCT04688749	Melanoma (Skin) Basal Cell Carc... Squamous Cell C... Dysplastic Nevu... Lentigo Maligna Seborrheic Kera... Lichen Planus-L... Carcinosarcoma	Electrical Impe...	8 Years - 90 Years	Aristotle University Of Thessaloniki

Spots Global Cancer Trial Database for melanocytes

Every month we try and update this database with for melanocytes cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for melanocytes

Every month we try and update this database with for melanocytes cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for melanocytes cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.