Neoplasms

Skin and Connective Tissue Diseases

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Nervous System Diseases

Symptoms and General Pathology

Behaviors and Mental Disorders

Breast Neoplasms

Memory Disorders

Breast Diseases

Skin Diseases

Neurobehavioral Manifestations

Neurologic Manifestations

All Drugs and Chemicals

Hormones

Patients perform neuropsychological, psycho-pathological and quality of life assessments, and sleep tests

Healthy volunteers perform neuropsychological, psycho-pathological and quality of life assessments, and sleep tests

Patients and Healthy volunteers perform neuropsychological, psycho-pathological and quality of life assessments, and sleep tests

Neuropsychological, psycho-pathological and quality of life assessments

Hormonotherapy

The results of this study will contribute to a better understanding of prospective memory deficit processes in breast cancer in relation to sleep disorders frequently reported in this pathology. In the long term, a better understanding will make it possible to envisage appropriate treatments to compensate for these memory difficulties and to improve the autonomy of the patients.

50 patients including:

* 25 patients being treated with adjuvant hormone therapy (Group A)
* 25 patients not receiving adjuvant hormone therapy (Group B)
* 25 healthy volunteers

Study of the Functioning of Prospective Memory in Breast Cancer and the Influence of Sleep

Institut National de la Santé Et de la Recherche Médicale, France

Centre Francois Baclesse

Substance Related Disorders

Cognitive Dysfunction

Chemotherapy-Related Cognitive Impairment

Cognition Disorders

Neurocognitive Disorders

Mental Disorders

Psychotic Disorders

Drug-Related Side Effects and Adverse Reactions

Chemically-Induced Disorders

Computer-based Cognitive Training

Henry W Mahncke, PhD

The investigators hypothesize that continuous active interaction with environments that are demanding to sensory, cognitive, and motor systems, together with imbedded rewards for successful performance, will help improve memory and cognitive functioning in patients suffering from "chemobrain".

Breast cancer is the most common malignancy in women in the United States, with an estimated 211,240 new cases of invasive breast cancer diagnosed among women, and 1,700 diagnosed in men, in 2005. While cure rates have improved significantly, chemotherapy for breast cancer is associated with a number of negative side effects. One of which is a deficit in cognitive function, a condition commonly referred to as "chemobrain". While the debate about cognitive decline being a result of chemotherapy is still ongoing, there is clear evidence of cognitive decline in women with breast cancer post-chemotherapy. Cognitive decline is often reported to affect memory, attention, executive functioning and information processing speed.

Studies suggest that incidence of "chemobrain" ranges from 17% - 75% in women who have undergone chemotherapy.This cognitive impairment affects quality of life by impacting patients' ability to concentrate, make decisions and to fulfill family, career, and community responsibilities.

Although there is uncertainty about the mechanisms that can lead to this cognitive decline, there is a pressing need to identify interventions that will alleviate its symptoms and help breast cancer survivors recover their cognitive functioning and resume their roles and activities at the pre-cancer level.

Brain plasticity refers to the brain's capacity for physical and functional change; it is this capacity that explains how experience induces learning throughout life. On the basis of a growing body of literature in the fields of psychophysics, neurology, neuropsychology, and brain plasticity, we hypothesize that the brain processing machinery can be refined, elaborated, and strengthened through rigorous training and learning. The purpose of this study is to investigate if such training can improve cognitive functioning.

We hypothesize that continuous active interaction with environments that are demanding to sensory, cognitive, and motor systems, together with imbedded rewards for successful performance will help improve memory and cognitive functioning in patients suffering from "chemobrain".

Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment

Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment, A Pilot Study

Posit Science Corporation

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Study of the Functioning of Prospective Memory in Breast Cancer and the Influence of Sleep	NCT03420105	Breast Cancer Memory Disorder...	Neuropsychologi... Hormonotherapy	18 Years - 70 Years	Centre Francois Baclesse
Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment	NCT00387062	Breast Cancer Cognitive Sympt... Memory Disorder...	Computer-based ...	21 Years -	Posit Science Corporation
Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment	NCT00387062	Breast Cancer Cognitive Sympt... Memory Disorder...	Computer-based ...	21 Years -	Posit Science Corporation
Study of the Functioning of Prospective Memory in Breast Cancer and the Influence of Sleep	NCT03420105	Breast Cancer Memory Disorder...	Neuropsychologi... Hormonotherapy	18 Years - 70 Years	Centre Francois Baclesse

Spots Global Cancer Trial Database for memory disorders