Neoplasms

Symptoms and General Pathology

All Conditions

Musculoskeletal Diseases

Rare Diseases

Neoplasm Metastasis

Osteosarcoma

Bone Neoplasms

Neoplastic Processes

Bone Diseases

To assess the early recovery will be used 1 minute sit to stand, Numeric Rating scale to assess pain, incentive spirometer to assess vital capacity, Borg modified scale to assess dyspnea.

assessment of the early recovery after wedge resection surgery

marco cotti, pt

mattia morri, pt

After "wedge resection" surgery, the physiotherapy programs proposed in the literature are heterogeneous and there are few data on the outcomes of such treatments in an oncological population for bone cancer.

The aim of the study is to describe the early rehabilitation process after wedge resection surgery secondary to bone tumor pulmonary mestasasis, highlightining the possible functional recovery in the short and medium term after surgery and indentifying the possible prognostic factors.

In Italy, the incidence of primary bone tumors is around 0.8-1 case per 100,000 inhabitants, therefore an estimated 500 new cases of primary malignant bone tumors are estimated each year, affecting more frequently in children and young people. The presence of pulmonary metastasis occurs in 30% of the population with bone cancer and is the most common site of metastasis. Where possible, the elective treatment of lung metastases is ablative surgery and the wedge resection technique is also commonly used in the event of repeated metastasis over time. Pulmonary wedge resection surgery does not follow the anatomical limits of the lung but it is customized according to the metastatic area to be removed, thus differentiating itself from lobectomies and other thoracotomy surgical techniques.

The trend of vital capacity (CV) and forced expiratory volume in 1s (FEV1), after wedge resection surgery, significantly decrease at 3 months compared to the preoperative evaluation, while at 12 months the CV returns to values close to the preoperative ones and FEV1 remains significantly lower. Rehabilitation treatment is part of the multidisciplinary approach for this type of patient in order to prevent post-surgical respiratory complications (PPC) and shoulder girdle dysfunctions, in the treatment of pain and in the recovery of respiratory volumes. Several authors, describing the physiotherapy treatment techniques, include breathing exercises (Active Cycle Breathing Techniques), early mobilization exercises for the lower limbs and the use of volume incentives. The physiotherapy treatment programs proposed in the literature are heterogeneous and there are no data on the feasibility of such treatments in an oncological population for bone cancer.

Patients are enrolled consecutively in a ward of an italian hospital specialized in bone tumor surgery.

Early Recovery After "Wedge Resection" Surgery to Remove Lung Mestastasis Secondary to Bone Cancer.

Rehabilitation Treatment and Early Recovery After "Wedge Resection" for Pulmonary Metastasis Secondary to Bone Cancer: an Observational Study.

The test requires the person to stand up from a chair, without the help of the arms, fully extending their knees, and sit down the greatest number of times in the time of one minute.

numeric rating scale (from 0 (no pain) to 10 (worst possible pain))

the vital capacity will be assess with incentive spirometer named "respirex"

beats per minute; it will be assess with pulse oximeter

dyspnea (shortness of breath, sometimes described as "air hunger") it will be assess using Borg Modified Scale, from 0 to 10, when 0 means "none" (better outcome) and 10 means "maximum" (worse outcome).

Istituto Ortopedico Rizzoli

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Digestive System Diseases

Urinary Bladder Neoplasms

Neoplastic Cells, Circulating

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Hematinics

All Drugs and Chemicals

Liver Extracts

Metastatic cancer patients (with liver and/or lung metastasis) who will receive molecularly targeted therapy based on genomic testing data

Gastrointestinal cancer patients (with liver and/or lung metastasis) who will receive 3rd line treatments or enrolled on a targeted therapy treatment trial

Bladder cancer patients (with liver and/or lung metastasis) who will receive systemic treatment

A blood sample will be collected once, prior to treatment.

Blood Draw

Andrew Z Wang, MD

The purpose of this prospective, non-randomized, single-center pilot exploratory study is to investigate whether established circulating tumor cell (CTC) cultures have a similar response to targeted therapy treatment as the in vivo (patients') disease.

This study will isolate circulating tumor cells (CTCs) from blood samples taken from patients with liver and/or lung metastases who will receive systemic treatments. The CTCs will be cultured and given the same treatment as the patient received. The main goals of this project are 1) to assess CTC cultures' treatment response and compare the in vitro response to the clinical response, and 2) determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CTC cultures' response in predicting clinical response including complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD).

Relationship Between Circulating Tumor Cell Cultures' Treatment Response and Clinical Outcomes

LCCC 1938: Investigating the Relationship Between Circulating Tumor Cell Cultures Treatment Response and Clinical Outcomes

To estimate the agreement between CTC cultures' response to treatment, dichotomized as either yes or no response, to the clinical response in patients to treatment, dichotomized as either progressive disease (PD) versus complete response (CR), partial response (PR), or stable disease (SD)

To determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CTC cultures' response in predicting clinical response including complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Early Recovery After "Wedge Resection" Surgery to Remove Lung Mestastasis Secondary to Bone Cancer.	NCT05310539	Metastasis Lung Bone Neoplasm	assessment of t...	12 Years -	Istituto Ortopedico Rizzoli
Early Recovery After "Wedge Resection" Surgery to Remove Lung Mestastasis Secondary to Bone Cancer.	NCT05310539	Metastasis Lung Bone Neoplasm	assessment of t...	12 Years -	Istituto Ortopedico Rizzoli
Relationship Between Circulating Tumor Cell Cultures' Treatment Response and Clinical Outcomes	NCT04280640	Cancer Metastasis Lung Metastasis to L... Circulating Tum... Gastrointestina... Bladder Cancer	Blood Draw	18 Years -	UNC Lineberger Comprehensive Cancer Center
Relationship Between Circulating Tumor Cell Cultures' Treatment Response and Clinical Outcomes	NCT04280640	Cancer Metastasis Lung Metastasis to L... Circulating Tum... Gastrointestina... Bladder Cancer	Blood Draw	18 Years -	UNC Lineberger Comprehensive Cancer Center
Relationship Between Circulating Tumor Cell Cultures' Treatment Response and Clinical Outcomes	NCT04280640	Cancer Metastasis Lung Metastasis to L... Circulating Tum... Gastrointestina... Bladder Cancer	Blood Draw	18 Years -	UNC Lineberger Comprehensive Cancer Center

Spots Global Cancer Trial Database for metastasis lung