Symptoms and General Pathology

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Polycystic Ovary Syndrome

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Female Urogenital Diseases and Pregnancy Complications

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Patients will receive Metformin (1500 mg orally/day) for 12 weeks .

Patients will receive Empagliflozin (25 mg orally/day) for 12 weeks.

Patients will receive Linagliptin (10 mg orally/day) for 12 weeks

This study is to compare the efficacy of Empagliflozin or Linagliptin as an alternative to Metformin for treatment of non-diabetic patients with polycystic ovary syndrome (PCOS)

Empagliflozin 25 mg

Linagliptin 10 mg

Metformin 1500 mg

Haidy M Sami, Master

Noha A Hamdy, PhD

Ahmed I ElMallah, PhD

Hanan N Abdel Hafez, PhD

Haidi M Sami, Master

The study aims to compare the efficacy of Empagliflozin or Linagliptin as an alternative to Metformin for treatment of non-diabetic patients with polycystic ovary syndrome (PCOS).

Patients with polycystic ovary syndrome will be randomized to three arms:

* Metformin (standard care)
* Empagliflozin or Linagliptin Resolution of the syndrome in addition to normalization of sex hormones, metabolic and inflammatory parameters will be tested

This study is for the treatment of polycystic ovary syndrome (PCOS)

Efficacy of Empagliflozin or Linagliptin as an Alternative to Metformin for Treatment of Polycystic Ovary Syndrome

A Comparative Clinical Study Evaluating the Efficacy of Empagliflozin or Linagliptin as an Alternative to Metformin for Treatment of Polycystic Ovary Syndrome in Egyptian Women

total testosterone \& sex hormone binding globulin (SHBG)

Total cholesterol, Low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), triglycerides (TG), atherogenic index I, II

Alexandria University

Professor of Pharmacology & Therapeutics, Faculty of Pharmacy, Alexandria University

Nutritional and Metabolic Diseases

Obesity

Micronutrients

Hematinics

Other Dietary Supplements

Vitamins

Insulin

Insulin, Globin Zinc

Inositol

Folic Acid

Vitamin B Complex

Trace Elements

Folate

Vitamin B9

metformin 1500 mg

myoinositol 1500 mg

The aim of this study is to compare the effects of six months treatment of two insulin-lowering therapies on the clinical and endocrine-metabolic parameters in obese women affected by polycystic ovary syndrome. The study group includes 40 patients, randomly allocated to subgroup A (metformin 1500 mg/day) and subgroup B (myo-inositol 1500 mg/day). The investigations include menstrual pattern and hirsutism score evaluation, hormonal assays, oral glucose tolerance test, euglycemic hyperinsulinaemic clamp and lipid profile at baseline and after six months of treatment.

Myo-inositol Versus Metformin in Obese Women With Polycystic Ovary Syndrome

Myo-inositol Versus Metformin: Effects of Six Months Treatment on Clinical, Endocrine and Metabolic Features in Obese Women With Polycystic Ovary Syndrome

Area under the curve insulin post oral glucose tolerance test (μUI/ML/180min), M value of euglycemic hyperinsulinaemic clamp(mg/kg/min).

Catholic University of the Sacred Heart

principal investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Efficacy of Empagliflozin or Linagliptin as an Alternative to Metformin for Treatment of Polycystic Ovary Syndrome	NCT05200793	Polycystic Ovar...	Empagliflozin 2... Linagliptin 10 ... Metformin 1500 ...	18 Years - 40 Years	Alexandria University
Myo-inositol Versus Metformin in Obese Women With Polycystic Ovary Syndrome	NCT01791647	Polycystic Ovar...	metformin 1500 ... myoinositol 150...	18 Years - 35 Years	Catholic University of the Sacred Heart

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