Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Behaviors and Mental Disorders

Syndrome

Polycystic Ovary Syndrome

Behavior, Addictive

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Hypoglycemic Agents

All Drugs and Chemicals

Micronutrients

Hematinics

Vitamins

Metformin

Folic Acid

Vitamin B Complex

Trace Elements

Folinic Acid

Folate

Vitamin B9

metformin plus placebo

metformin 850 mg cp, 2 cps daily plus folic acid 0.4 mg daily

Metformin plus folic acid

Placebo 1 cp daily plus folic acid 0.4 mg daily

placebo plus folic acid

placebo alone

Fulvio Zullo, MD

Stefano Palomba, MD

A more recent prospective nonrandomized placebo-controlled double-blind clinical study demonstrated that metformin exerts a slight but significant deleterious effect on serum homocysteine (Hcy) levels in patients with PCOS, and supplementation with folate is useful to increase the beneficial effect of metformin on the vascular endothelium.

PCOS (cases) and non-PCOS (controls) pregnant women were enrolled. Cases will be randomized in four treatment groups: metformin plus placebo (group A1), metformin plus folic acid (group A2), placebo plus folic acid (group A3), placebo alone (group A4). Controls will not received any treatment (group B). Clinical and biochemical assessment (including serum markers of implantation), Doppler velocimetry of the uterine arteries, and trophoblastic invasion at histological and immunohistochemical evaluation.

Changes in clinical and biochemical data under treatment, pattern of Doppler velocimetry at the uterine arteries, and trophoblastic invasion were evaluated.

Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women

Effect of Metformin With or Without Folate Addiction on Uterine Blood Flow and Trophoblastic Invasion in Pregnant Patients With Polycystic Ovary Syndrome

Istologic evaluation of trophoblastic ivasion,

Ultrasonographyc assessment of Doppler velocimetry measurements of the uterine artery.

University Magna Graecia

Department of Obstetrics and Gynecology

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women	NCT01115140	Pregnancy Polycystic Ovar...	metformin plus ... Metformin plus ... placebo plus fo... placebo alone	18 Years - 38 Years	University Magna Graecia
Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women	NCT01115140	Pregnancy Polycystic Ovar...	metformin plus ... Metformin plus ... placebo plus fo... placebo alone	18 Years - 38 Years	University Magna Graecia

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