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Non-obese or obese patients that underwent an open liver resection for all indications

Non-obese or obese patients that underwent a minimally invasive liver resection for all indications

A liver resection performed by minimally invasive (keyhole) surgery

Minimally invasive liver resection

Despite the worldwide increase of both obesity and use of minimally invasive liver surgery(MILS), evidence regarding the safety and eventual benefits of MILS in obese patients is scarce. The aim of this study is therefore to compare the outcomes of non-obese and obese patients(BMI 18.5-29.9 and BMI≥30, respectively) undergoing MILS and OLS, and to assess trends in MILS use among obese patients. In this retrospective cohort study, patients operated at 20 hospitals in eight countries(2009-2019) will be included and the characteristics and outcomes of non-obese and obese patients will be compared. Thereafter, the outcomes of MILS and OLS were compared in both groups after propensity-score matching(PSM). Changes in the adoption of MILS during the study period will be investigated.

Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes

Indications, Trends, and Perioperative Outcomes of Minimally Invasive and Open Liver Surgery in Non-obese and Obese Patients: an International Multicentre Propensity Score Matched Retrospective Cohort Study of 9963 Patients.

The data of this study will be available from the corresponding author, Professor Mohammed Abu Hilal, upon reasonable request. The data are not publicly available since this could compromise the privacy of research participants.

Severe complications (Clavien-Dindo grade 3a or higher) related to the surgical procedure

Overall complications related to the surgical procedure

The length of hospital stay for the surgical procedure

Proportion of patients in whom a microscopically radical resection of both the primary colorectal carcinoma and the liver metastases was performed.

Proportion of patients in whom a microscopically radical resection was performed

Intra-operative conversion to an open or hand-assisted procedure in the minimally invasive group

Occurrence of post-hepatectomy liver failure (ISGLS definition and classification)

Occurrence of bile leak (ISGLS definition and classification)

Intraoperative red blood cell transfusion

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes	NCT05475054	Liver Cancer Liver Metastase... Obesity	Minimally invas...	18 Years -	Fondazione Poliambulanza Istituto Ospedaliero
Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes	NCT05475054	Liver Cancer Liver Metastase... Obesity	Minimally invas...	18 Years -	Fondazione Poliambulanza Istituto Ospedaliero

Spots Global Cancer Trial Database for minimally invasive liver resection