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Liver Extracts

Minimally invasive resection of the primary colorectal carcinoma and liver metastases in two stages. The liver metastases or the colorectal carcinoma can be resected during the first surgical procedure.

Minimally invasive resection of both the primary colorectal carcinoma and the liver metastases in one procedure.

One minimally invasive surgical procedure wherein both the primary colorectal carcinoma and the liver metastases are removed.

Minimally invasive simultaneous resection

Two minimally invasive surgical procedures wherein the primary colorectal carcinoma and the liver metastases are removed

Minimally invasive two-stage resection

Jasper Sijberden, MD

Professor Mohammed Abu Hilal, MD PhD

Dennis Wicherts, PhD

Joep Knol, PhD

Mathieu D'Hondt, PhD

Bart van Geluwe, PhD

Ibrahim Dagher, PhD

Panagiotis Lainas, PhD

Gregor Stavrou, MD

Roberto Troisi, PhD

Gaetano Luglio, PhD

Elio Jovine, PhD

Michele Masetti, MD

Simone Nicosia, MD

Fabrizio di Benedetto, PhD

Paolo Magistri, MD

Raffaele Dalla Valle, PhD

Mario Giuffrida, MD

Felice Giuliante, PhD

Roberto Persiani, PhD

Mohammed Abu Hilal, PhD

Luca Aldrighetti, PhD

Marco Vivarelli, PhD

Mario Guerrieri, PhD

Andrea Benedetti Cacciaguerra, MD

Alessandro Ferrero, PhD

Paolo Massucco, MD

Umberto Cillo, PhD

Enrico Gringeri, PhD

Jacopo Lanari, MD

Edoardo Rosso, MD

Ronald van Dam, PhD

Jarno Melenhorst, PhD

Rutger-Jan Swijnenburg, PhD

Bjørn Edwin, PhD

Sheraz Yaqub, PhD

Asmund Fretland, PhD

Mikhail Efanov, PhD

Mikhail Danilov, PhD

Aslan Baychorov, PhD

Benedetto Ielpo, PhD

Fernando Rotellar, PhD

Aali Sheen, PhD

Steve White, PhD

Rafael Díaz-Nieto, PhD

John Primrose, PhD

Alex Mirnezami, PhD

Krishna Menon, PhD

Amyn Haji, MD

Somaiah Aroori, PhD

Robert Sutcliffe, MD

Shazad Ashraf, MD

The LIVACOR - Trial is a European wide, randomized controlled, open-label, multicenter trial. Patients with synchronous colorectal liver metastases (CRLMs) and primary colorectal tumor are considered eligible and will be randomized between minimally invasive (MI) combined or staged colorectal resection (all colectomies, including high anterior resection) and liver resection of up to three segments.

LIVACOR Trial: Minimally Invasive LIVer And Simultaneous COlorectal Resection

A patient is considered functionally recovered from a surgical procedure when several pre-specified criteria have been met.

Proportion of patients in whom a microscopically radical resection of both the primary colorectal carcinoma and the liver metastases was performed.

The length of hospital stay for the surgical procedure(s)

A patient's functional recovery will also be assessed using the Fitbit smartwatch.

Morbidity related to the surgical procedure(s)

Bile leakage occurring after the liver resection

Anastomotic leakage occurring after the colorectal resection

Intra-operative conversion to an open or hand-assisted procedure

Proportion of patients who is unexpectedly readmitted after the surgical procedure(s)

The physical, social and emotional well-being of the patient; assessed using the EuroQol 5d and European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30 instruments.

All reasons that may cause delay in discharge after the patient has recovered functionally, such as administrative reasons, patient confidence, logistics problems, etc.

All costs that are associated with the operation, including in-hospital costs and out of hospital costs, such as home care, work absence, etc.

The proportion of patients which is free of recurrence of the malignant disease after resection of both the primary colorectal carcinoma and the liver metastases.

The proportion of patients which is alive after resection of both the primary colorectal carcinoma and the liver metastases.

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

University Hospital Southampton NHS Foundation Trust

University Hospital Birmingham NHS Foundation Trust

Liverpool University Hospitals NHS Foundation Trust

King's College Hospital NHS Trust

Manchester University NHS Foundation Trust

Newcastle-upon-Tyne Hospitals NHS Trust

University Hospital Plymouth NHS Trust

Mauriziano Umberto I Hospital

University Hospital Padova

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

San Raffaele University Hospital, Italy

Ospedali Riuniti Ancona

Azienda Usl di Bologna

Azienda Ospedaliero-Universitaria di Modena

Federico II University

Parma University Hospital

Klinikum Saarbrücken, Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Chirurgische Onkologie

Spots Global Cancer Trial Database for minimally invasive simultaneous resection