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Hemorrhage

Myoma

Leiomyoma

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Neoplasms, Connective Tissue

Connective Tissue Diseases

Central Nervous System Depressants

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Reproductive Control Agents

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Anesthetics

Oxytocin

Misoprostol

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receiving a preoperative rectal dose of 800 ug of misoprostol half an hour before surgery

After the induction of general anaesthesia (GA), an infusion of 40 IU oxytocin in 500 ml normal saline was started at the rate of 250 ml/hour

Misoprostol 200mcg Tab

after the induction of general anaesthesia (GA), an infusion of 40 IU oxytocin in 500 ml normal saline was started at the rate of 250 ml/hour

waleed M El-khayat, MD

mona s Moghazy, MD

Mohammad A Taymour, MD

Waleed M Elkhyat

Tarek N Anees, MD

Uterine leiomyomas, or fibroids, are common benign tumors among women, especially those over 35 years old. They can cause various issues, including heavy menstrual bleeding, anemia, pelvic pain, and pressure symptoms. Surgery is often necessary for symptomatic fibroids, with hysterectomy recommended for women over 40 and myomectomy for those wishing to preserve their uterus. Myomectomy can be performed using different surgical approaches but can be associated with significant morbidity, particularly major blood loss, especially in abdominal myomectomy, where up to 20% of women may require blood transfusion.

Various interventions have been introduced to reduce bleeding during myomectomy, such as tourniquets, bupivacaine plus epinephrine infiltration, vasopressin injection, preoperative GnRH agonist administration, and preoperative ascorbic acid injection. However, these strategies may have complications, be ineffective, expensive, or require extra steps.

Oxytocin, primarily secreted from the pituitary gland, is crucial for uterine contraction during labor and delivery, and is used to prevent postpartum uterine atony and bleeding. However, caution is needed in its use, especially in women with heart disease or hypovolemia.

Misoprostol, a prostaglandin E1 analogue, can reduce bleeding during myomectomy by promoting myometrial contractions and reducing uterine artery blood flow. It can be administered via multiple routes, with rectal administration showing advantages in maintaining high plasma concentrations during surgery. Studies have investigated the effectiveness of single preoperative rectal doses of misoprostol versus preoperative oxytocin in reducing bleeding during abdominal myomectomy.

20-48 years old with symptomatic uterine myoma indicating operative management, abnormal uterine bleeding or bulk-related symptoms, females with infertility or recurrent pregnancy loss, pressure symptoms, and large myoma(s).

Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy

The Efficacy Of Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy

which was measured at the end of surgery by calculating the sum of blood in the suction bottle and the blood absorbed in the sponges. Dry sponges were weighed before the surgery and the blood-soaked sponges were weighed at the end of the surgery

Cairo University

lecturer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy	NCT06325501	Myoma;Uterus	Misoprostol 200... Oxytocin	20 Years - 48 Years	Cairo University
Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy	NCT06325501	Myoma;Uterus	Misoprostol 200... Oxytocin	20 Years - 48 Years	Cairo University

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