The patients can choose between three modality of EX:

1. Autonomous supervised training : a personalized activity is proposed. People choosing this modality have a written material, in which all the exercise, the activity, the frequency, the duration, the intensity are specifically described and reported, to perform the training at home. A training diary and 7 meetings (face to face, or skype or other modality) are proposed for monitoring the intervention.
2. Personal training program: a personalized activity is proposed. Patients are followed individually in a gym contest by a qualified kinesiologist.
3. Group training program: the training is performed in a small group, supervised and monitored by a qualified kinesiologist. The instructor-user ratio is 1:4 - 1:8, depending on the functional conditions and the heterogeneity of the participants.

Physical exercise

Massimo Lanza

The "CHOICE!" study is an exercise program following the recommendation of the American College of Sports Science for cancer patients. The aims of the intervention are to test the safety and feasibility of a structured program, letting patients choose the modality of delivery. Secondary endpoints include exercise health-related skills and quality of life. The program considers the preferences of exercise of cancer survivors, giving the possibility to choose the exercise modality (autonomous, with a personal trainer or group class). This program will be tested in different cancer populations with different study designs based on different patients cohort (i.e., RCT or single-arm).

The CHOiCE includes different substudies, with different study designs, i.e., RCT, single arm.

"CHOiCE"! Choose Health: Oncological Patients Cenetered Exercise

Different Modalities of Exercise for Physical Activity Promotion in Cancer Patients

Adverse events will categorize according to the Common Terminology Criteria for Adverse Events (version 5.0)

The number of patients considered eligible dividing the number of subjects who meet inclusion criteria

The number of patients randomized dividing the number of subjects considered eligible

Measured by the total number of exercise sessions attended

Defined as a participant who leaves the study for any reason prior to completing the 12-week (24 session) exercise program. All reasons for drop out will be reported.

Using the Isometric Leg Press strength test

Calculated usign the waist and hip circumferences

Using the Physical Activity Enjoyment Scale (PACES), ranging from 0 (no enjoyment) to 75 (max enjoyment)

Using European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ C-30), ranging from 0 (lowest QoL) to 100 (highest QoL)

Using the Godin's Leisure Time Exercise Questionnaire (GLTEQ). GLTEQ inquires about frequency of vigorous, moderate and mild intensity EX as defined by Godin. Subsequently, each frequency is multiplied by its correspondent metabolic equivalent of the task (MET), i.e. vigorous\*9; moderate\*5; mild\*3. A Leisure Score Index (LSI) was calculated, using the sum of vigorous and moderate components. Based on LSI patients were then classified as active (if LSI≥ 24) and insufficiently active (if LSI\<24) according to the American College of Sport Medicine Physical Activity Guidelines.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
"CHOiCE"! Choose Health: Oncological Patients Cenetered Exercise	NCT04226508	Mixed Cancer	Physical exerci...	18 Years - 90 Years	Universita di Verona
"CHOiCE"! Choose Health: Oncological Patients Cenetered Exercise	NCT04226508	Mixed Cancer	Physical exerci...	18 Years - 90 Years	Universita di Verona

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