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Mohs micrographic surgery + Autologus patch formed from 18 ml venous blood sample collected from the patient + polymycin-terramycin B ointment and a Jelonet applied on top of the patch.

Mohs micropgraphic surgery + Polymycin-terramycin B ointment + dry wound dressing

A patch of consisting of platelets, leucocytes and fibrin, formed by the patients own blood sample.

MMS + Autologous patch

Mohs micrographic surgery (standard of care) (wounds will heal by secondary intention healing)

MMS and secondary intention healing

Katrine E Karmisholt, MD, PhD

Anna A Harager, Bsc

Katrine E Karmisholt, Ph.D.

Anna A Harager

The primary objects of this study is to explore the potential effect of the autologous patch to optimize wound healing after skin cancer surgery with Mohs micrographic surgery (MMS) in the face in a randomized controlled trial comparing autologous patch healing versus secondary intention healing.

Blinded photo assesment of wound healing by two independent trained clinical doctors.

Autologous Patch Healing vs. Secondary Intention Healing After Mohs Micrographic Surgery

Autologous Patch Healing vs. Secondary Intention Healing After Mohs Micrographic Surgery - A Randomized Controlled Trial

Two indenpendent trained clinical doctors will evaluate clinical photos. Wounds will be evaluated fully epithelialized yes/no.

Clinical photos from day 11-13 will be evaluated. Wounds will be evaluated 50% fully epithelialized yes/no.

Trans epidermal water loss (TEWL) will be meassured at day 11-13 and day 18-20. The TEWL will be meassured on the wound healing site and the contralateral site of the patient's face as a control.

The POSAS observer scores scar components with regards to: Vascularity, pigmentation, thickness, surface area, relief and pliability. The collected sum of scores will range from minimum 6 points to maximum 60 points.

Swab test for microbiome analysis will be conducted at day 1 and day 11-13.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Autologous Patch Healing vs. Secondary Intention Healing After Mohs Micrographic Surgery	NCT05170035	Skin Cancer Basal Cell Carc...	MMS + Autologou... MMS and seconda...	18 Years - 100 Years	Bispebjerg Hospital
Autologous Patch Healing vs. Secondary Intention Healing After Mohs Micrographic Surgery	NCT05170035	Skin Cancer Basal Cell Carc...	MMS + Autologou... MMS and seconda...	18 Years - 100 Years	Bispebjerg Hospital

Spots Global Cancer Trial Database for mms and secondary intention healing